CSF proteins of inflammation, proteolysis and lipid transport define preclinical AD and progression to AD dementia in cognitively unimpaired individuals

This preclinical AD CSF proteome study identified a panel of 12-CSF markers detecting amyloid positivity and clinical progression to AD with high accuracy; some of these CSF proteins related to immune function, neurotrophic processes, energy metabolism and endolysosomal functioning (e.g., ITGB2, CLEC5A, IGFBP-1, CST3) changed before amyloid positivity is established.

This research is part of the neurodegeneration research program of Amsterdam Neuroscience. Alzheimer Center Amsterdam is supported by Stichting Alzheimer Nederland and Stichting VUmc fonds. The chair Wiesje van der Flier is supported by the Pasman stichting. This study was supported by Alzheimer Nederland (CT, MC), ZonMW (#73305095007), Health ~ Holland, Topsector Life Sciences & Health (PPP-allowance; #LSHM20106). MC is supported by the attraction talent fellowship of Comunidad de Madrid (2018-T2/BMD-11885) and "PROYECTOS I + D + I - 2020"- Retos de investigación from the Ministerio Español de Ciencia e innovación (PID2020-115613RA-I00). The SCIENCe study has received funding from Gieskes-Strijbis Fonds and Stichting Dioraphte. WF and CT are recipient of TAP-Dementia, a ZonMW funded project (#10510032120003) under the Dutch National Dementia Strategy.

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Article

Published version

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English

Subjects and keywords

Alzheimer, Malaltia d'

Publisher

BioMed Central

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Molecular Neurodegeneration. 2024;19(1):82

info:eu-repo/grantAgreement/ES/2PE/PID2020-115613RA-I00

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