dc.contributor.author
Campo, Marta del
dc.contributor.author
Quesada, Carlos
dc.contributor.author
Vermunt, Lisa
dc.contributor.author
Peeters, Carel F. W.
dc.contributor.author
Hok-A-Hin, Yanaika S.
dc.contributor.author
Trieu, Calvin
dc.contributor.author
den Braber, Anouk
dc.contributor.author
Verberk, Inge M. W.
dc.contributor.author
Visser, Pieter Jelle
dc.contributor.author
Tijms, Betty M.
dc.contributor.author
van der Flier, Wiesje M.
dc.contributor.author
Teunissen, Charlotte E.
dc.date.accessioned
2026-01-15T00:48:17Z
dc.date.available
2026-01-15T00:48:17Z
dc.date.issued
2026-01-13T18:44:49Z
dc.date.issued
2026-01-13T18:44:49Z
dc.date.issued
2026-01-13T18:44:49Z
dc.identifier
Del Campo M, Quesada C, Vermunt L, Peeters CFW, Hok-A-Hin YS, Trieu C, Braber AD, Verberk IMW, Visser PJ, Tijms BM, Van Der Flier WM, Teunissen CE. CSF proteins of inflammation, proteolysis and lipid transport define preclinical AD and progression to AD dementia in cognitively unimpaired individuals. Mol Neurodegener. 2024;19(1):82. DOI: 10.1186/s13024-024-00767-z
dc.identifier
https://hdl.handle.net/10230/72200
dc.identifier
http://dx.doi.org/10.1186/s13024-024-00767-z
dc.identifier.uri
http://hdl.handle.net/10230/72200
dc.description.abstract
This preclinical AD CSF proteome study identified a panel of 12-CSF markers detecting amyloid positivity and clinical progression to AD with high accuracy; some of these CSF proteins related to immune function, neurotrophic processes, energy metabolism and endolysosomal functioning (e.g., ITGB2, CLEC5A, IGFBP-1, CST3) changed before amyloid positivity is established.
dc.description.abstract
This research is part of the neurodegeneration research program of Amsterdam Neuroscience. Alzheimer Center Amsterdam is supported by Stichting Alzheimer Nederland and Stichting VUmc fonds. The chair Wiesje van der Flier is supported by the Pasman stichting. This study was supported by Alzheimer Nederland (CT, MC), ZonMW (#73305095007), Health ~ Holland, Topsector Life Sciences & Health (PPP-allowance; #LSHM20106). MC is supported by the attraction talent fellowship of Comunidad de Madrid (2018-T2/BMD-11885) and "PROYECTOS I + D + I - 2020"- Retos de investigación from the Ministerio Español de Ciencia e innovación (PID2020-115613RA-I00). The SCIENCe study has received funding from Gieskes-Strijbis Fonds and Stichting Dioraphte. WF and CT are recipient of TAP-Dementia, a ZonMW funded project (#10510032120003) under the Dutch National Dementia Strategy.
dc.format
application/pdf
dc.format
application/pdf
dc.publisher
BioMed Central
dc.relation
Molecular Neurodegeneration. 2024;19(1):82
dc.relation
info:eu-repo/grantAgreement/ES/2PE/PID2020-115613RA-I00
dc.rights
© The Author(s) 2024. Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
dc.rights
http://creativecommons.org/licenses/by/4.0/
dc.rights
info:eu-repo/semantics/openAccess
dc.subject
Alzheimer, Malaltia d'
dc.title
CSF proteins of inflammation, proteolysis and lipid transport define preclinical AD and progression to AD dementia in cognitively unimpaired individuals
dc.type
info:eu-repo/semantics/article
dc.type
info:eu-repo/semantics/publishedVersion
