Title:
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Synthesis and evaluation of novel furanones as biofilm inhibitors in opportunistic human pathogens
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Author:
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Gómez, Andromeda-Celeste; Lyons, Thérèse; Mamat, Uwe; Yero, Daniel; Bravo, Marc; Daura i Ribera, Xavier; Elshafee, Osama; Brunke, Sascha; Gahan, Cormac G.M.; O'Driscoll, Michelle; Gibert, Isidre; O'Sullivan, Timothy P.
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Abstract:
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Diseases caused by biofilm-forming pathogens are becoming increasingly prevalent and represent a major threat to human health. This trend has prompted a search for novel inhibitors of microbial biofilms which could, for example, be used to potentiate existing antibiotics. Naturally-occurring, halogenated furanones isolated from marine algae have proven to be effective biofilm inhibitors in several bacterial species. In this work, we report the synthesis of a library of novel furanones and their subsequent evaluation as biofilm inhibitors in several opportunistic human pathogens including S. enterica, S. aureus, E. coli, S. maltophilia, P. aeruginosa and C. albicans. A number of the most potent compounds were subjected to further analysis by confocal laser-scanning microscopy for their effects on P. aeruginosa and C. albicans biofilms individually, in addition to mixed polymicrobial biofilms. Lastly, we investigated the impact of a promising candidate on survival rates in vivo using a Galleria mellonella model. |
Subject(s):
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-Furanones -Biofilms -Quorum sensing -Salmonella enterica -Staphylococcus aureus -Pseudomonas aeruginosa -Escherichia coli -Stenotrophomonas maltophilia -Candida albicans |
Rights:
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open access
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https://creativecommons.org/licenses/by/4.0/ |
Document type:
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Article |
Published by:
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Share:
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Uri:
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https://ddd.uab.cat/record/270489
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