Título:
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Antibacterial films based on MOF composites that release iodine passively or upon triggering by near-infrared light
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Autor/a:
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Han, Xu; Boix, Gerard; Balcerzak, Mateusz; Moriones, Oscar Hernando; Cano-Sarabia, Mary; Cortés Garmendia, M. Pilar; Bastús, Neus G.; Puntes, Víctor; Llagostera Casas, Montserrat; Imaz, Inhar; Maspoch Comamala, Daniel; Boix, Gerard
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Abstract:
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This work was supported by the CERCA Program/Generalitat de Catalunya. |
Abstract:
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Multidrug-resistant bacteria have become a global health problem for which new prophylactic strategies are now needed, including surface-coatings for hospital spaces and medical equipment. This work reports the preparation and functional validation of a metal-organic framework (MOF) based composite for the triggered controlled release of iodine, an antimicrobial element that does not generate resistance. It comprises beads of the iodophilic MOF UiO-66 containing encapsulated gold nanorods (AuNRs) coated with a silica shell. Irradiation of the AuNRs with near-infrared light (NIR) provokes a photothermal effect and the resultant heat actively liberates the iodine. After validating the performance of this composite, it is integrated into a polymer for the development of antibacterial films. This work assesses the adsorption of iodine into these composite films, as well as its passive long-term release and active light-triggered. Finally, this work validates the antibacterial activity of the composite films in vitro against gram-positive and gram-negative bacteria. The findings will surely inform the development of new prophylactic treatments. |
Fecha de creación:
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13-12-2022 |
Materia(s):
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-Antimicrobial -Composites -Gold nanorods -Iodine -Metal-organic frameworks -Photothermal -Triggered release |
Derechos:
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open access
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https://creativecommons.org/licenses/by-nc-nd/4.0/ |
Tipo de documento:
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Article |
Editor:
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Uri:
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https://ddd.uab.cat/record/266363
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