dc.contributor.author |
Gómez-González, Jacobo |
dc.contributor.author |
Peña, Diego G. |
dc.contributor.author |
Barka, Ghofrane |
dc.contributor.author |
Sciortino, Giuseppe |
dc.contributor.author |
Maréchal, Jean-Didier |
dc.contributor.author |
Vázquez López, Miguel |
dc.contributor.author |
Vázquez, M. Eugenio |
dc.date |
2018 |
dc.date.accessioned |
2022-12-12T05:42:19Z |
dc.date.available |
2022-12-12T05:42:19Z |
dc.date.issued |
2022-12-12 |
dc.identifier |
https://ddd.uab.cat/record/253717 |
dc.identifier |
urn:10.3389/fchem.2018.00520 |
dc.identifier |
urn:oai:ddd.uab.cat:253717 |
dc.identifier |
urn:pmcid:PMC6218460 |
dc.identifier |
urn:pmc-uid:6218460 |
dc.identifier |
urn:pmid:30425980 |
dc.identifier |
urn:oai:pubmedcentral.nih.gov:6218460 |
dc.identifier |
urn:oai:egreta.uab.cat:publications/794dc3a7-a3d2-484f-8a75-13ec3587c86a |
dc.identifier |
urn:scopus_id:85056261913 |
dc.identifier |
urn:articleid:22962646v6p520 |
dc.identifier.uri |
http://hdl.handle.net/2072/527779 |
dc.format |
application/pdf |
dc.language |
eng |
dc.publisher |
|
dc.relation |
Ministerio de Economía y Competitividad CTQ2015-70698-R |
dc.relation |
Agencia Estatal de Investigación CTQ2017-87889-P |
dc.relation |
Agència de Gestió d'Ajuts Universitaris i de Recerca 2017/SGR-1323 |
dc.relation |
Frontiers in chemistry ; Vol. 6 (October 2018), art. 520 |
dc.rights |
open access |
dc.rights |
Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original. |
dc.rights |
https://creativecommons.org/licenses/by/4.0/ |
dc.subject |
Metallopeptide |
dc.subject |
Self-assembly water |
dc.subject |
DNA recognition |
dc.subject |
Enantioselectivity |
dc.subject |
Peptide motifs |
dc.subject |
Coordination chemistry |
dc.title |
Directed Self-Assembly of Trimeric DNA-Bindingchiral Miniprotein Helicates |
dc.type |
Article |
dc.description.abstract |
We propose that peptides are highly versatile platforms for the precise design of supramolecular metal architectures, and particularly, for the controlled assembly of helicates. In this context, we show that the bacteriophage T4 Fibritin foldon (T4Ff) can been engineered on its N-terminus with metal-chelating 2,2'-bipyridine units that stereoselectively assemble in the presence of Fe(II) into parallel, three-stranded peptide helicates with preferred helical orientation. Modeling studies support the proposed self-assembly and the stability of the final helicate. Furthermore, we show that these designed mini-metalloproteins selectively recognize three-way DNA junctions over double-stranded DNA. |