dc.contributor.author |
Matas, Jessica |
dc.contributor.author |
Llorenç, Victor |
dc.contributor.author |
Fonollosa, Alex |
dc.contributor.author |
Diaz Valle, David |
dc.contributor.author |
Esquinas, Cristina |
dc.contributor.author |
de la Maza, Maria Teresa Sainz |
dc.contributor.author |
Figueras-Roca, Marc |
dc.contributor.author |
Artaraz, Joseba |
dc.contributor.author |
Berasategui, Barbara |
dc.contributor.author |
Mesquida, Marina |
dc.contributor.author |
Adan Civera, Alfredo |
dc.contributor.author |
Molins, Blanca |
dc.contributor.author |
Universitat Autònoma de Barcelona |
dc.date |
2020 |
dc.identifier |
https://ddd.uab.cat/record/253020 |
dc.identifier |
urn:10.3389/fimmu.2020.579005 |
dc.identifier |
urn:oai:ddd.uab.cat:253020 |
dc.identifier |
urn:pmcid:PMC7545109 |
dc.identifier |
urn:pmc-uid:7545109 |
dc.identifier |
urn:pmid:33101305 |
dc.identifier |
urn:oai:pubmedcentral.nih.gov:7545109 |
dc.format |
application/pdf |
dc.language |
eng |
dc.publisher |
|
dc.relation |
Ministerio de Economía y Competitividad PI13/00217 |
dc.relation |
Ministerio de Economía y Competitividad RD16/0008 |
dc.relation |
Agència de Gestió d'Ajuts Universitaris i de Recerca 2017SGR0701 |
dc.relation |
Frontiers in immunology ; Vol. 11 (september 2020) |
dc.rights |
open access |
dc.rights |
Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original. |
dc.rights |
https://creativecommons.org/licenses/by/4.0/ |
dc.subject |
Macular edema |
dc.subject |
Uveitis |
dc.subject |
Cytokines |
dc.subject |
Regulatory T cells |
dc.subject |
Biomarkers |
dc.title |
Systemic Regulatory T Cells and IL-6 as Prognostic Factors for Anatomical Improvement of Uveitic Macular Edema |
dc.type |
Article |
dc.description.abstract |
To investigate whether systemic immune mediators and circulating regulatory T cells (Tregs) could be prognostic factors for anatomic outcomes in macular edema secondary to non-infectious uveitis (UME). Multicenter, prospective, observational, 12-month follow-up study of 60 patients with UME. Macular edema was defined as central subfield thickness (CST) > 300 μm measured with spectral domain optical coherence tomography (SD-OCT). Serum samples and peripheral blood mononuclear cells (PBMC) were obtained from venous blood extraction at baseline. Serum levels of IL-1β, IL-6, IL-8, IL-17, MCP-1, TNF-α, IL-10, and VEGF were determined by Luminex. Tregs population, defined as CD3 + CD4 + FoxP3 + in PBMC, was determined by flow cytometry. Main outcome measure was the predictive association between searched mediators and CST sustained improvement, defined as CST < 300 microns or a 20% CST decrease, at 6 months maintained until 12-months compared to baseline levels. Multivariate logistic regression analysis showed an association between CST sustained improvement at 12 months follow-up and IL-6 and Tregs baseline levels. Higher IL-6 levels were associated with less events of UME improvement (OR: 0.67, 95% CI (0.45-1.00), P = 0.042), whereas higher levels of Tregs favored such improvement (OR: 1.25, 95% CI: 1.12-2.56, P = 0.049). Increased levels of Tregs and reduced levels of IL-6 in serum may be prognostic factors of sustained anatomical improvement in UME. These findings could enforce the opportunity to develop more efficient and personalized therapeutic approaches to improve long-term visual prognosis in patients with UME |