dc.contributor.author |
Vizán, Pedro |
dc.contributor.author |
Gutiérrez, Arantxa |
dc.contributor.author |
Espejo, Isabel |
dc.contributor.author |
García-Montolio, Marc |
dc.contributor.author |
Lange, Martin |
dc.contributor.author |
Carretero i Romay, Ana |
dc.contributor.author |
Lafzi, Atefeh |
dc.contributor.author |
de Andrés-Aguayo, Luisa |
dc.contributor.author |
Blanco, Enrique |
dc.contributor.author |
Thambyrajah, Roshana |
dc.contributor.author |
Graf, Thomas |
dc.contributor.author |
Heyn, Holger |
dc.contributor.author |
Bigas Salvans, Anna |
dc.contributor.author |
Di Croce, Luciano |
dc.date |
2020 |
dc.identifier |
https://ddd.uab.cat/record/252856 |
dc.identifier |
urn:10.1126/sciadv.abb2745 |
dc.identifier |
urn:oai:ddd.uab.cat:252856 |
dc.identifier |
urn:pmcid:PMC7406347 |
dc.identifier |
urn:pmc-uid:7406347 |
dc.identifier |
urn:oai:pubmedcentral.nih.gov:7406347 |
dc.identifier |
urn:oai:egreta.uab.cat:publications/9465bdd7-6205-40a3-87bc-5b5e1163bd8b |
dc.identifier |
urn:pmid:32821835 |
dc.identifier |
urn:scopus_id:85089805689 |
dc.format |
application/pdf |
dc.language |
eng |
dc.publisher |
|
dc.relation |
European Commission. Horizon 2020 675752 |
dc.relation |
Ministerio de Ciencia e Innovación SAF2017-89109-P |
dc.relation |
Ministerio de Ciencia e Innovación SAF2016-75613-R |
dc.relation |
Ministerio de Economía, Industria y Competitividad BFU2016-75008-P |
dc.relation |
Science advances ; Vol. 6 (august 2020) |
dc.rights |
open access |
dc.rights |
Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original. |
dc.rights |
https://creativecommons.org/licenses/by/4.0/ |
dc.subject |
Taxonomy via GenBank |
dc.subject |
Nucleotide |
dc.subject |
SRA |
dc.subject |
Protein |
dc.title |
The Polycomb-associated factor PHF19 controls hematopoietic stem cell state and differentiation |
dc.type |
Article |
dc.description.abstract |
Phf19, a Polycomb subunit, controls hematopoietic stem cells identity and differentiation. Adult hematopoietic stem cells (HSCs) are rare multipotent cells in bone marrow that are responsible for generating all blood cell types. HSCs are a heterogeneous group of cells with high plasticity, in part, conferred by epigenetic mechanisms. PHF19, a subunit of the Polycomb repressive complex 2 (PRC2), is preferentially expressed in mouse hematopoietic precursors. Here, we now show that, in stark contrast to results published for other PRC2 subunits, genetic depletion of Phf19 increases HSC identity and quiescence. While proliferation of HSCs is normally triggered by forced mobilization, defects in differentiation impede long-term correct blood production, eventually leading to aberrant hematopoiesis. At molecular level, PHF19 deletion triggers a redistribution of the histone repressive mark H3K27me3, which notably accumulates at blood lineage-specific genes. Our results provide novel insights into how epigenetic mechanisms determine HSC identity, control differentiation, and are key for proper hematopoiesis. |