Título:
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Use of serum KL-6 level for detecting patients with restrictive allograft syndrome after lung transplantation
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Autor/a:
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Berastegui García, Cristina; Gómez-Ollés, Susana; Mendoza-Valderrey, Alberto; Pereira-Veiga, Thais; Culebras Amigo, Mario; Monforte, Víctor; Sáez-Giménez, Berta; López-Meseguer, Manuel; Sintes-Permanyer, Helena; Ruiz de Miguel, Victoria; Bravo, Carlos; Sacanell, Judith; Ramon, María-Antonia; Romero, Laura; Deu, Maria; Román, Antonio; Universitat Autònoma de Barcelona
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Abstract:
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KL-6 is an antigen produced mainly by damaged type II pneumocytes that is involved in interstitial lung disease. Chronic lung allograft dysfunction (CLAD) after lung transplantation (LT) is a major concern for LT clinicians, especially in patients with restrictive allograft syndrome (RAS). We investigated KL-6 levels in serum and bronchoalveolar lavage fluid (BALF) as a potential biomarker of the RAS phenotype. Levels of KL-6 in serum and BALF were measured in 73 bilateral LT recipients, and patients were categorized into 4 groups: stable (ST), infection (LTI), bronchiolitis obliterans syndrome (BOS), and RAS. We also studied a healthy cohort to determine reference values for serum KL-6. The highest levels of KL-6 were found in the serum of patients with RAS (918 [487.8-1638] U/mL). No differences were found for levels of KL-6 in BALF. Using a cut-off value of 465 U/mL serum KL-6 levels was able to differentiate RAS patients from BOS patients with a sensitivity of 100% and a specificity of 75%. Furthermore, higher serum KL-6 levels were associated with a decline in Forced Vital Capacity (FVC) at 6 months after sample collection. Therefore, KL-6 in serum may well be a potential biomarker for differentiating between the BOS and RAS phenotypes of CLAD in LT recipients |
Derechos:
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open access
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Uri:
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https://ddd.uab.cat/record/252403
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