dc.contributor.author |
Iglesias-González, Maria |
dc.contributor.author |
Boigues, Marc |
dc.contributor.author |
Sanagustin, David |
dc.contributor.author |
Giralt López, Maria |
dc.contributor.author |
Cuevas-Esteban, Jorge |
dc.contributor.author |
Martínez-Cáceres, Eva |
dc.contributor.author |
Diez-Quevedo, Crisanto |
dc.date |
2021 |
dc.identifier |
https://ddd.uab.cat/record/250549 |
dc.identifier |
urn:10.1016/j.bbih.2021.100405 |
dc.identifier |
urn:oai:ddd.uab.cat:250549 |
dc.identifier |
urn:pmcid:PMC8664764 |
dc.identifier |
urn:pmc-uid:8664764 |
dc.identifier |
urn:pmid:34927104 |
dc.identifier |
urn:oai:pubmedcentral.nih.gov:8664764 |
dc.format |
application/pdf |
dc.language |
eng |
dc.publisher |
|
dc.relation |
Brain, Behavior, & Immunity - Health ; Vol. 19 (february 2022) |
dc.rights |
open access |
dc.rights |
Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, i la comunicació pública de l'obra, sempre que no sigui amb finalitats comercials, i sempre que es reconegui l'autoria de l'obra original. No es permet la creació d'obres derivades. |
dc.rights |
https://creativecommons.org/licenses/by-nc-nd/4.0/ |
dc.subject |
Inflammation |
dc.subject |
Immunity |
dc.subject |
Depression |
dc.subject |
Anxiety |
dc.subject |
COVID-19 |
dc.subject |
Cytokines |
dc.title |
Association of serum interleukin-6 and C-reactive protein with depressive and adjustment disorders in COVID-19 inpatients |
dc.type |
Article |
dc.description.abstract |
Immune mechanisms are part of the pathophysiology of mental disorders, although their role remains controversial. In depressive disorders a chronic low-grade inflammatory process is observed, with higher interleukin-6 (IL-6) values. Furthermore, in SARS-CoV2 infection, which is closely related to depressive disorders, there is a proinflammatory cascade of cytokines that causes systemic inflammation. The present study evaluates the relationship between IL-6 and C-reactive protein (CRP) serum levels and the presence of depressive and adjustment disorders in a sample of 1851 patients admitted to hospital for SARS-CoV2 infection from March to November 2020. Concentrations of IL-6 and CRP were determined within the first 72 h at admission and compared among groups of patients according to previous history and current presence of depression or adjustment disorders. IL-6 serum levels were significantly higher in the group of patients with depression and adjustment disorders compared to patients without such disorders (114.25 pg/mL (SD, 225.44) vs. 86.41 (SD, 202.97)), even after adjusting for several confounders. Similar results were obtained for CRP (103.94 mg/L (SD, 91.16) vs. 90.14 (SD, 85.73)). The absolute levels of IL-6 and CRP were higher than those of previous depression studies, and differences were only found for the subgroup of De Novo depressive or adjustment disorders. Serum concentrations of IL-6 and CRP are higher in COVID-19 patients with De Novo but not persistent depressive or adjustment disorders. Clinical features such as fatigue, asthenia, anhedonia, or anxiety can be the basis for this finding. |