dc.contributor.author |
Borràs, Jordi |
dc.contributor.author |
Foster, Julie |
dc.contributor.author |
Kashani, Roxana |
dc.contributor.author |
Melendez-Alafort, L. |
dc.contributor.author |
Sosabowski, Jane |
dc.contributor.author |
Suades Ortuño, Joan |
dc.contributor.author |
Barnadas Rodríguez, Ramon |
dc.date |
2021 |
dc.date.accessioned |
2022-10-30T11:45:45Z |
dc.date.available |
2022-10-30T11:45:45Z |
dc.date.issued |
2022-10-30 |
dc.identifier |
https://ddd.uab.cat/record/250125 |
dc.identifier |
urn:10.3390/molecules26082373 |
dc.identifier |
urn:oai:ddd.uab.cat:250125 |
dc.identifier |
urn:scopus_id:85105152662 |
dc.identifier |
urn:articleid:14203049v26n8p2373 |
dc.identifier |
urn:oai:egreta.uab.cat:publications/8fb61348-ab7d-4205-89fd-734c2768ff4b |
dc.identifier |
urn:wos_id:000644615700001 |
dc.identifier |
urn:pmid:33921789 |
dc.identifier |
urn:pmc-uid:8074163 |
dc.identifier |
urn:pmcid:PMC8074163 |
dc.identifier |
urn:oai:pubmedcentral.nih.gov:8074163 |
dc.identifier.uri |
http://hdl.handle.net/2072/524136 |
dc.format |
application/pdf |
dc.language |
eng |
dc.publisher |
|
dc.relation |
Ministerio de Economía y Competitividad BIO2015-67358-C2-2-P |
dc.relation |
Ministerio de Economía y Competitividad CTQ2015-70371-REDT |
dc.relation |
Agència de Gestió d'Ajuts Universitaris i de Recerca 2017/SGR-795 |
dc.relation |
Molecules ; Vol. 26, Núm. 8 (April 2021), art. 2373 |
dc.rights |
open access |
dc.rights |
Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original. |
dc.rights |
https://creativecommons.org/licenses/by/4.0/ |
dc.subject |
Technetium |
dc.subject |
Carbonyl |
dc.subject |
Folic |
dc.subject |
Transmetallation |
dc.subject |
Radiopharmaceutical |
dc.subject |
Rhenium |
dc.title |
New bioconjugated technetium and rhenium folates synthesized by transmetallation reaction with zinc derivatives |
dc.type |
Article |
dc.description.abstract |
The zinc dithiocarbamates functionalized with folic acid 2 and 3 were synthesized with a simple straightforward method, using an appropriated folic acid derivative and a functionalized zinc dithiocarbamate (1). Zinc complexes 2 and 3 show very low solubilities in water, making them useful for preparing Tc-99m radiopharmaceuticals with a potentially high molar activity. Thus, the transmetallation reaction in water medium between the zinc complexes 2 or 3 and the cation fac-[ Tc(H O) (CO) ], in the presence of the monodentate ligand TPPTS, leads to the formation of the 2 + 1 complexes fac-[ Tc(CO) (SS)(P)] bioconjugated to folic acid (2 and 3). In spite of the low solubility of 2 and 3 in water, the reaction yield is higher than 95%, and the excess zinc reagent is easily removed by centrifugation. The Tc-99m complexes were characterized by comparing their HPLC with those of the homologous rhenium complexes (2 and 3) previously synthesized and characterized by standard methods. Preliminary in vivo studies with 2 and 3 indicate low specific binding to folate receptors. In summary, Tc-99m folates 2 and 3 were prepared in high yields, using a one-pot transmetallation reaction with low soluble zinc dithiocarbamates (>1 ppm), at moderate temperature, without needing a subsequent purification step. |