RECERCAT Principal
>
Universitat Autònoma de Barcelona
>
Articles escrits per personal UAB o publicats per la universitat
>
Visualizar documento
| Título: | Beneficial effects of dietary supplementation with green tea catechins and cocoa flavanols on aging-related regressive changes in the mouse neuromuscular system |
|---|---|
| Autor/a: | Gras, Sílvia; Blasco, Alba; Mòdol-Caballero, Guillem; Tarabal, Olga; Casanovas, Anna; Piedrafita, Lídia; Barranco, Alejandro; Das, Tapas; Rueda, Ricardo; Pereira, Suzette L.; Navarro, X. (Xavier); Esquerda, Josep E.; Calderó, Jordi |
| Abstract: | Besides skeletal muscle wasting, sarcopenia entails morphological and molecular changes in distinct components of the neuromuscular system, including spinal cord motoneurons (MNs) and neuromuscular junctions (NMJs); moreover, noticeable microgliosis has also been observed around aged MNs. Here we examined the impact of two flavonoid-enriched diets containing either green tea extract (GTE) catechins or cocoa flavanols on age-associated regressive changes in the neuromuscular system of C57BL/6J mice. Compared to control mice, GTE- and cocoa-supplementation significantly improved the survival rate of mice, reduced the proportion of fibers with lipofuscin aggregates and central nuclei, and increased the density of satellite cells in skeletal muscles. Additionally, both supplements significantly augmented the number of innervated NMJs and their degree of maturity compared to controls. GTE, but not cocoa, prominently increased the density of VAChT and VGluT2 afferent synapses on MNs, which were lost in control aged spinal cords; conversely, cocoa, but not GTE, significantly augmented the proportion of VGluT1 afferent synapses on aged MNs. Moreover, GTE, but not cocoa, reduced aging-associated microgliosis and increased the proportion of neuroprotective microglial phenotypes. Our data indicate that certain plant flavonoids may be beneficial in the nutritional management of age-related deterioration of the neuromuscular system. |
| Materia(s): | -Sarcopenia -Green tea -Neuromuscular system -Aging -Cocoa |
| Derechos: | open access
Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original. https://creativecommons.org/licenses/by/4.0/ |
| Tipo de documento: | Article |
| Editor: | |
| Compartir: |
|
| Uri: | https://ddd.uab.cat/record/248870 |
Documentos relacionados
Otros documentos del mismo autor/a
Blasco, Alba; Gras, Sílvia; Mòdol Caballero, Guillem; Tarabal, Olga; Llagostera Casanovas, Anna; Piedrafita Llorens, Lídia; Barranco, Alejandro; Das, Tapas; Pereira, Suzette L.; Navarro, X. (Xavier); Rueda Cabrera, Ricardo; Esquerda, Josep E.; Calderó, Jordi
Blasco Carmona, Alba; Gras Artells, Sílvia; Mòdol-Caballero, Guillem; Tarabal Mostazo, Olga; Casanovas i Llorens, Anna; Piedrafita Llorens, Lídia; Barranco, Alejandro; Das, Tapas; Pereira, Suzette L.; Navarro, Xavier; Rueda, Ricardo; Esquerda Colell, Josep; Calderó i Pardo, Jordi
Mòdol-Caballero, Guillem; Herrando-Grabulosa, Mireia; García-Lareu, Belén; Solanes, Neus; Verdés, Sergi; Osta, Rosario; Francos Quijorna, Isaac; López Vales, Rubén; Calvo, Ana Cristina; Bosch i Merino, Assumpció; Navarro, X. (Xavier)
Marsal Tebé, Jordi; Fiol, Conxa; Esquerda, Josep E.
Puigdellívol Sánchez, Anna; Giralt Torroella, Albert; Casanovas, Anna; Alberch i Vié, Jordi; Prats Galino, Alberto