dc.contributor.author |
Yue, Jicheng |
dc.contributor.author |
López, José M. |
dc.contributor.author |
Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular |
dc.date |
2020 |
dc.date.accessioned |
2022-10-30T01:46:17Z |
dc.date.available |
2022-10-30T01:46:17Z |
dc.date.issued |
2022-10-30 |
dc.identifier |
https://ddd.uab.cat/record/241317 |
dc.identifier |
urn:10.3390/ijms21072346 |
dc.identifier |
urn:oai:ddd.uab.cat:241317 |
dc.identifier |
urn:scopus_id:85082791079 |
dc.identifier |
urn:articleid:14220067v21n7p2346 |
dc.identifier |
urn:pmid:32231094 |
dc.identifier |
urn:pmc-uid:7177758 |
dc.identifier |
urn:pmcid:PMC7177758 |
dc.identifier |
urn:oai:pubmedcentral.nih.gov:7177758 |
dc.identifier.uri |
http://hdl.handle.net/2072/523776 |
dc.format |
application/pdf |
dc.language |
eng |
dc.publisher |
|
dc.relation |
Ministerio de Ciencia e Innovación BFU2010-15978 |
dc.relation |
International journal of molecular sciences ; Vol. 21 Núm. 7 (march 2020), p. 2346 |
dc.rights |
open access |
dc.rights |
Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original. |
dc.rights |
https://creativecommons.org/licenses/by/4.0/ |
dc.subject |
Apoptosis |
dc.subject |
Protein kinases |
dc.subject |
Caspases |
dc.subject |
Signaling |
dc.subject |
MAPK |
dc.subject |
P38 |
dc.subject |
JNK |
dc.subject |
ERK |
dc.subject |
Oocytes |
dc.subject |
Feedback loops |
dc.title |
Understanding MAPK signaling pathways in apoptosis |
dc.type |
Article de revisió |
dc.description.abstract |
MAPK (mitogen-activated protein kinase) signaling pathways regulate a variety of biological processes through multiple cellular mechanisms. In most of these processes, such as apoptosis, MAPKs have a dual role since they can act as activators or inhibitors, depending on the cell type and the stimulus. In this review, we present the main pro-and anti-apoptotic mechanisms regulated by MAPKs, as well as the crosstalk observed between some MAPKs. We also describe the basic signaling properties of MAPKs (ultrasensitivity, hysteresis, digital response), and the presence of different positive feedback loops in apoptosis. We provide a simple guide to predict MAPKs' behavior, based on the intensity and duration of the stimulus. Finally, we consider the role of MAPKs in osmostress-induced apoptosis by using Xenopus oocytes as a cell model. As we will see, apoptosis is plagued with multiple positive feedback loops. We hope this review will help to understand how MAPK signaling pathways engage irreversible cellular decisions. |