dc.contributor.author |
Bolivar-Prados, Mireia |
dc.contributor.author |
Rofes, L. |
dc.contributor.author |
Arreola, Viridiana |
dc.contributor.author |
Guida, S. |
dc.contributor.author |
Nascimento, Weslania Viviane. |
dc.contributor.author |
Martin, Alberto |
dc.contributor.author |
Vilardell, N. |
dc.contributor.author |
Ortega, Omar |
dc.contributor.author |
Ripken, D. |
dc.contributor.author |
Lansink, M. |
dc.contributor.author |
Clavé i Civit, Pere |
dc.date |
2019 |
dc.identifier |
https://ddd.uab.cat/record/223874 |
dc.identifier |
urn:10.1111/nmo.13695 |
dc.identifier |
urn:oai:ddd.uab.cat:223874 |
dc.identifier |
urn:scopus_id:85070703071 |
dc.identifier |
urn:articleid:13652982v31n11e13695 |
dc.identifier |
urn:pmid:31402571 |
dc.identifier |
urn:pmc-uid:6852432 |
dc.identifier |
urn:pmcid:PMC6852432 |
dc.identifier |
urn:oai:pubmedcentral.nih.gov:6852432 |
dc.format |
application/pdf |
dc.language |
eng |
dc.publisher |
|
dc.relation |
Instituto de Salud Carlos III PI14/00453 |
dc.relation |
Instituto de Salud Carlos III PI18/00241 |
dc.relation |
Instituto de Salud Carlos III INT15/00026 |
dc.relation |
Instituto de Salud Carlos III INT16/00111 |
dc.relation |
Neurogastroenterology and Motility ; Vol. 31 Núm. 11 (november 2019), p. e13695 |
dc.rights |
open access |
dc.rights |
Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original. |
dc.rights |
https://creativecommons.org/licenses/by/4.0/ |
dc.subject |
Spiration |
dc.subject |
Deglutition disorders |
dc.subject |
Shear viscosity |
dc.subject |
Stroke |
dc.subject |
Swallow response |
dc.subject |
Thickener |
dc.subject |
Xanthan gum |
dc.title |
Effect of a gum-based thickener on the safety of swallowing in patients with poststroke oropharyngeal dysphagia |
dc.type |
Article |
dc.description.abstract |
Altres ajuts: This work has been supported by Danone Nutricia Research, Fundació Salut del Consorci Sanitari del Maresme, Furega (Fundació per a la Recerca en Gastroenterologia) and Centro de Investigación en Red en Enfermedades Hepáticas y Digestivas (CIBERehd). |
dc.description.abstract |
Background: Increasing viscosity with thickening agents is a valid therapeutic strategy for oropharyngeal dysphagia (OD). To assess the therapeutic effect of a xanthan gum-based thickener (Nutilis Clear) at six viscosities compared with thin liquid in poststroke OD (PSOD) patients. Methods: A total of 120 patients with PSOD were studied in this controlled, multiple-dose, fixed-order, and single-blind study using videofluoroscopy (VFSS). A series of boluses of 10 mL thin liquid and 2000, 1400, 800, 450, 250, and 150 mPa s viscosities were given in duplicate, interrupted in case of aspiration. We assessed the safety and efficacy of swallow and the kinematics of the swallow response. Key Results: A total of 41.2% patients had safe swallow at thin liquid which significantly increased for all viscosities from 71.9% at 150 mPa s to 95.6% at 1400 mPa s (P <.001). PAS score (3.7 ± 2.3) at thin liquid was also reduced by increasing bolus viscosity (P <.001). The prevalence of patients with aspiration at thin liquid was 17.5% and decreased at all viscosities (P <.01), except at 150 mPa s. Increasing viscosity shortened time to laryngeal vestibule closure (LVC) at all viscosities (P <.01) and reduced bolus velocity at ≥450 mPa s (P <.05). The prevalence of patients with pharyngeal residue at each viscosity 37.7%-44.7% was similar to that at thin liquid (41.2%). Conclusions and Inferences: The prevalence of unsafe swallow with thin liquids is very high in PSOD. Increasing shear bolus viscosity with this xanthan gum-based thickener significantly increased the safety of swallow in patients with PSOD in a viscosity-dependent manner without increasing the prevalence of pharyngeal residue. |