dc.contributor.author |
Gokhman, David |
dc.contributor.author |
Nissim-Rafinia, Malka |
dc.contributor.author |
Agranat-Tamir, Lily |
dc.contributor.author |
Housman, Genevieve |
dc.contributor.author |
García Perez, Raquel |
dc.contributor.author |
Lizano, Esther |
dc.contributor.author |
Cheronet, Olivia |
dc.contributor.author |
Mallick, Swapan |
dc.contributor.author |
Nieves-Colón, Maria A. |
dc.contributor.author |
Li, Heng |
dc.contributor.author |
Alpaslan-Roodenberg, Songül |
dc.contributor.author |
Novak, Mario |
dc.contributor.author |
Gu, Hongcang |
dc.contributor.author |
Osinski, Jason M. |
dc.contributor.author |
Ferrando-Bernal, Manuel |
dc.contributor.author |
Gelabert, Pere |
dc.contributor.author |
Lipende, Iddi |
dc.contributor.author |
Mjungu, Deus |
dc.contributor.author |
Kondova, Ivanela |
dc.contributor.author |
Bontrop, Ronald |
dc.contributor.author |
Kullmer, Ottmar |
dc.contributor.author |
Weber, Gerhard |
dc.contributor.author |
Shahar, Tal |
dc.contributor.author |
Dvir-Ginzberg, Mona |
dc.contributor.author |
Faerman, Marina |
dc.contributor.author |
Quillen, Ellen E. |
dc.contributor.author |
Meissner, Alexander |
dc.contributor.author |
Lahav, Yonatan |
dc.contributor.author |
Kandel, Leonid |
dc.contributor.author |
Liebergall, Meir |
dc.contributor.author |
Prada, María E. |
dc.contributor.author |
Vidal, Julio M. |
dc.contributor.author |
Gronostajski, Richard M. |
dc.contributor.author |
Stone, Anne C. |
dc.contributor.author |
Yakir, Benjamin |
dc.contributor.author |
Lalueza-Fox, Carles |
dc.contributor.author |
Pinhasi, Ron |
dc.contributor.author |
Reich, David |
dc.contributor.author |
Marques-Bonet, Tomas |
dc.contributor.author |
Meshorer, Eran |
dc.contributor.author |
Carmel, Liran |
dc.date |
2020 |
dc.identifier |
https://ddd.uab.cat/record/234397 |
dc.identifier |
urn:10.1038/s41467-020-15020-6 |
dc.identifier |
urn:oai:ddd.uab.cat:234397 |
dc.identifier |
urn:scopus_id:85081232371 |
dc.identifier |
urn:articleid:20411723v11p1189 |
dc.identifier |
urn:pmid:32132541 |
dc.identifier |
urn:pmc-uid:7055320 |
dc.identifier |
urn:pmcid:PMC7055320 |
dc.identifier |
urn:oai:pubmedcentral.nih.gov:7055320 |
dc.format |
application/pdf |
dc.language |
eng |
dc.publisher |
|
dc.relation |
Ministerio de Economía y Competitividad BFU2017-86471-P |
dc.relation |
Ministerio de Economía y Competitividad BFU2015-64699-P |
dc.relation |
European Commission 263441 |
dc.relation |
Nature communications ; Vol. 11 (March 2020), art. 1189 |
dc.rights |
open access |
dc.rights |
Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original. |
dc.rights |
https://creativecommons.org/licenses/by/4.0/ |
dc.subject |
Adult |
dc.subject |
Aged |
dc.subject |
Animals |
dc.subject |
Cells Cultured |
dc.subject |
Child |
dc.subject |
Chondrocytes |
dc.subject |
DNA Methylation |
dc.subject |
DNA Ancient |
dc.subject |
Evolution Molecular |
dc.subject |
Face |
dc.subject |
Female |
dc.subject |
Gene Regulatory Networks |
dc.subject |
Genetic Speciation |
dc.subject |
Humans |
dc.subject |
Larynx |
dc.subject |
Male |
dc.subject |
Middle Aged |
dc.subject |
Neanderthals |
dc.subject |
Pan troglodytes |
dc.subject |
Phenotype |
dc.subject |
Phonation |
dc.subject |
Primary Cell Culture |
dc.subject |
Tongue |
dc.subject |
Vocal Cords |
dc.subject |
Vocalization Animal |
dc.title |
Differential DNA methylation of vocal and facial anatomy genes in modern humans |
dc.type |
Article |
dc.description.abstract |
Altres ajuts: Obra Social "La Caixa" i CERCA Programme/Generalitat de Catalunya |
dc.description.abstract |
Changes in potential regulatory elements are thought to be key drivers of phenotypic divergence. However, identifying changes to regulatory elements that underlie human-specific traits has proven very challenging. Here, we use 63 reconstructed and experimentally measured DNA methylation maps of ancient and present-day humans, as well as of six chimpanzees, to detect differentially methylated regions that likely emerged in modern humans after the split from Neanderthals and Denisovans. We show that genes associated with face and vocal tract anatomy went through particularly extensive methylation changes. Specifically, we identify widespread hypermethylation in a network of face- and voice-associated genes (SOX9, ACAN, COL2A1, NFIX and XYLT1). We propose that these repression patterns appeared after the split from Neanderthals and Denisovans, and that they might have played a key role in shaping the modern human face and vocal tract. |