Títol:
|
Luminescent silicon-based nanocarrier for drug delivery in colorectal cancer cells
|
Autor/a:
|
Marcelo, Gonçalo A.; Montpeyó Garcia-Moreno, David; Novio Vázquez, Fernando; Ruiz-Molina, Daniel; Lorenzo Rivera, Julia; Oliveira, Elisabete
|
Abstract:
|
Altres ajuts: F.N. thanks to COST Action CA17121. F.N. and J.L. thanks to COST Action CA15138. |
Abstract:
|
Nanocarriers sensitive to exogenous or endogenous stimuli emerged as an attractive alternative to target drug delivery, with inorganic silica mesoporous nanoparticles (MNs) playing a core role in the development of a new generation of non-toxic and tuneable nanocarriers. A sensitive nanovector (NANO1) comprising luminescent silicon quantum dots (SiQDs) and functionalized with MNs was synthesised and loaded with doxorubicin (DOX). NANO1 nanoparticles have a size of 74 ± 10 nm and DOX loading percentages of ca. 43%. As a control sample, a similar nanocarrier (NANO2), without SiQDs, was also synthesised and loaded with DOX. Release profile studies, in PBS, revealed the strong NANO1@DOX pH-dependant behaviour, with a pH 5.0 favouring the release of DOX to percentages of ca. 70%. Cytotoxicity assessments of both free and DOX-loaded nanocarriers were evaluated in human cell lines of colon, revealing both free drug and drug-loaded nanoparticles to be concentration-dependent. |
Matèries:
|
-Luminescence -Silicon quantum dots -Mesoporous silica nanoparticles -Drug delivery -Colorectal cancer cells -Doxorubicin |
Drets:
|
open access
Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, i la comunicació pública de l'obra, sempre que no sigui amb finalitats comercials, i sempre que es reconegui l'autoria de l'obra original. No es permet la creació d'obres derivades.
https://creativecommons.org/licenses/by-nc-nd/4.0/ |
Tipus de document:
|
Article |
Publicat per:
|
|
Compartir:
|
|
Uri:
|
https://ddd.uab.cat/record/233958
|