Title:
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Clinical Applicability of the Specific Risk Score of Dementia in Type 2 Diabetes in the Identification of Patients with Early Cognitive Impairment : results of the MOPEAD Study in Spain
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Author:
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Ortiz-Zúñiga, Ángel Michael; Rodriguez-Gómez, Octavio; Hernández, Cristina; Rodrigo, Adrian; Jamilis, Laura; Campo, Laura; Alegret, Montserrat; Boada, Mercè; Ciudin, Andreea; Simó Canonge, Rafael; Universitat Autònoma de Barcelona
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Abstract:
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Altres ajuts: This research was funded by the European Innovative Medicines Initiative (IMI2) Project-grant number 115985. |
Abstract:
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Introduction: Although the Diabetes Specific Dementia Risk Score (DSDRS) was proposed for predicting risk of dementia at 10 years, its usefulness as a screening tool is unknown. For this purpose, the European consortium MOPEAD included the DSDRS within the specific strategy for screening of cognitive impairment in type 2 diabetes (T2D) patients attended in a third-level hospital. Material and Methods: T2D patients > 65 years, without known cognitive impairment, attended in a third-level hospital, were evaluated. As per MOPEAD protocol, patients with MMSE ≤ 27 or DSDRS ≥ 7 were referred to the memory clinic for complete neuropsychological assessment. Results: 112 T2D patients were recruited. A total of 82 fulfilled the criteria for referral to the memory unit (43 of them declined referral: 48.8% for associated comorbidities, 37.2% lack of interest, 13.95% lack of social support). At the Fundació ACE's Memory Clinic, 34 cases (87.2%) of mild cognitive impairment (MCI) and 3 cases (7.7%) of dementia were diagnosed. The predictive value of DSDRS ≥ 7 as a screening tool of cognitive impairment was AUROC = 0.739, p 0.024, CI 95% (0.609-0.825). Conclusions: We found a high prevalence of unknown cognitive impairment in TD2 patients who attended a third-level hospital. The DSDRS was found to be a useful screening tool. The presence of associated comorbidities was the main factor of declining referral. |
Subject(s):
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-Type 2 diabetes -Mild cognitive impairment -Alzheimer's disease |
Rights:
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open access
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Document type:
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Article |
Published by:
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Uri:
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https://ddd.uab.cat/record/233406
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