dc.contributor.author |
Martínez-Riera, R. |
dc.contributor.author |
Pérez-Mañá, Clara |
dc.contributor.author |
Papaseit, Esther |
dc.contributor.author |
Fonseca, Francina |
dc.contributor.author |
de la Torre, Rafael |
dc.contributor.author |
Pizarro Lozano, Nieves |
dc.contributor.author |
Torrens, Marta |
dc.contributor.author |
Farre, Magi |
dc.date |
2019 |
dc.identifier |
https://ddd.uab.cat/record/223804 |
dc.identifier |
urn:10.3389/fphar.2019.00131 |
dc.identifier |
urn:oai:ddd.uab.cat:223804 |
dc.identifier |
urn:scopus_id:85065836921 |
dc.identifier |
urn:articleid:16639812v10nFEBp131 |
dc.identifier |
urn:oai:egreta.uab.cat:publications/f3c57ca2-b95d-4cd8-b97e-11f4669c101c |
dc.identifier |
urn:pmid:30873023 |
dc.identifier |
urn:pmc-uid:6400998 |
dc.identifier |
urn:pmcid:PMC6400998 |
dc.identifier |
urn:oai:pubmedcentral.nih.gov:6400998 |
dc.format |
application/pdf |
dc.language |
eng |
dc.publisher |
|
dc.relation |
Instituto de Salud Carlos III RD16-0017-0003 |
dc.relation |
Instituto de Salud Carlos III JR16-00020 |
dc.relation |
Instituto de Salud Carlos III RD16-0017-0010 |
dc.relation |
Frontiers in Pharmacology ; Vol. 10 Núm. FEB (2019), p. 131 |
dc.rights |
open access |
dc.rights |
Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original. |
dc.rights |
https://creativecommons.org/licenses/by/4.0/ |
dc.subject |
Soy extracts |
dc.subject |
Isoflavones, daidzein |
dc.subject |
Genistein |
dc.subject |
Aldehyde-dehydrogenase-2 enzyme |
dc.subject |
Alcohol |
dc.subject |
Clinical trial |
dc.title |
Soy isoflavone extract does not increase the intoxicating effects of acute alcohol ingestion in human volunteers |
dc.type |
Article |
dc.description.abstract |
Altres ajuts: This work was supported by grants from Ministerio de Sanidad, Política Social e Igualdad (Plan Nacional Sobre Drogas, PNSD 2015I054 and 2016I024). |
dc.description.abstract |
Soy beans contain isoflavones, including daidzein and genistein, with biological activities related to therapeutic effects in reducing osteoporosis, decreasing adverse menopausal manifestations, providing protection from cardiovascular diseases, and reducing hormone-dependent cancers and age-related cognitive-decline. Daidzein has been described as inhibiting the aldehyde-dehydrogenase-2 enzyme (ALDH2), and reducing alcohol use in clinical pilot studies. Our aim was to evaluate the possible interactions between a soy extract product and alcohol in a crossover, single blind, randomized study. Ten healthy male volunteers participated in two experimental sessions: one with a single dose of alcohol (0.5 g/kg, Vodka Absolut, Sweden), and the other with four capsules of a soy extract product (Super-Absorbable Soy Isoflavones, Life-Extension, United States) and, 2 h later, the same dose of alcohol. Results showed no differences in vital signs except a slightly higher significative reduction in diastolic blood pressure at 2, 3, 4, and 8 h after administration with alcohol alone in comparison with soy extract+alcohol. Ethanol-induced subjective and adverse effects were similar for both conditions with the exception of headache (higher at 8 h after alcohol alone). Our results demonstrate that a single dose of a soy isoflavone extract did not influence alcohol pharmacokinetics and pharmacological effects and did not induce any disulfiram-reaction symptoms. Soy extract and alcohol did not interact and can be administered safely. |