dc.contributor.author |
Perea-Gil, Isaac |
dc.contributor.author |
Prat-Vidal, Cristina |
dc.contributor.author |
Gálvez-Montón, Carolina |
dc.contributor.author |
Rudilla, F. |
dc.contributor.author |
Llucià-Valldeperas, Aida |
dc.contributor.author |
Soler-Botija, Carolina |
dc.contributor.author |
Iborra Egea, Oriol |
dc.contributor.author |
Díaz-Güemes, Idoia |
dc.contributor.author |
Crisóstomo, Verónica |
dc.contributor.author |
Sánchez-Margallo, Francisco M. |
dc.contributor.author |
Bayés-Genís, Antoni |
dc.date |
2016 |
dc.identifier |
https://ddd.uab.cat/record/195605 |
dc.identifier |
urn:10.1016/j.jacbts.2016.06.005 |
dc.identifier |
urn:oai:ddd.uab.cat:195605 |
dc.identifier |
urn:pmid:30167524 |
dc.identifier |
urn:pmcid:PMC6113410 |
dc.identifier |
urn:pmc-uid:6113410 |
dc.identifier |
urn:articleid:2452302Xv1p360 |
dc.identifier |
urn:scopus_id:85003015902 |
dc.identifier |
urn:altmetric_id:12064187 |
dc.identifier |
urn:oai:egreta.uab.cat:publications/219bc4fd-3d75-41f8-b558-f69897380445 |
dc.identifier |
urn:oai:pubmedcentral.nih.gov:6113410 |
dc.format |
application/pdf |
dc.language |
eng |
dc.publisher |
|
dc.relation |
Ministerio de Ciencia e Innovación SAF2014-59892-R |
dc.relation |
Instituto de Salud Carlos III FIS/TerCel/RD12/0019/0029 |
dc.relation |
Instituto de Salud Carlos III FIS/RIC/RD12/0042/0047 |
dc.relation |
Instituto de Salud Carlos III FIS/PI14/01682 |
dc.relation |
JACC: Basic to Translational Science ; Vol. 1 (august 2016), p. 360-372 |
dc.rights |
open access |
dc.rights |
Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, i la comunicació pública de l'obra, sempre que no sigui amb finalitats comercials, i sempre que es reconegui l'autoria de l'obra original. No es permet la creació d'obres derivades. |
dc.rights |
https://creativecommons.org/licenses/by-nc-nd/4.0/ |
dc.subject |
Adipose tissue-derived progenitor cells |
dc.subject |
Cardiac tissue engineering |
dc.subject |
Decellularized myocardial scaffold |
dc.subject |
Myocardial infarction |
dc.subject |
Pre-clinical model |
dc.subject |
ATDPC, adipose tissue-derived progenitor cells |
dc.subject |
CMR, cardiac magnetic resonance imaging |
dc.subject |
Ctni, cardiac troponin I |
dc.subject |
EMG, engineered myocardial graft |
dc.subject |
GFP, green fluorescent protein |
dc.subject |
IsoB4, isolectin B4 |
dc.subject |
LV, left ventricle/ventricular |
dc.subject |
LVEF, left ventricular ejection fraction |
dc.subject |
MI, myocardial infarction |
dc.subject |
Patdpc, porcine adipose tissue-derived progenitor cell |
dc.subject |
SMA, smooth muscle actin |
dc.title |
A Cell-Enriched Engineered Myocardial Graft Limits Infarct Size and Improves Cardiac Function |
dc.type |
Article |
dc.description.abstract |
Altres ajuts: Fundació La Marató de TV3 [201502; 201516]; Beca de Recerca Bàsica de l'Acadèmia de Ciències Mèdiques i de la Salut de Catalunya i de Balears 2015; Beca d'Investigació Bàsica de la Societat Catalana de Cardiologia 2015; Generalitat de Catalunya (SGR 2014); Sociedad Española de Cardiología; Fundació Privada Daniel Bravo Andreu |
dc.description.abstract |
Myocardial infarction (MI) remains a dreadful disease around the world, causing irreversible sequelae that shorten life expectancy and reduce quality of life despite current treatment. Here, the authors engineered a cell-enriched myocardial graft, composed of a decellularized myocardial matrix refilled with adipose tissue-derived progenitor cells (EMG-ATDPC). Once applied over the infarcted area in the swine MI model, the EMG-ATDPC improved cardiac function, reduced infarct size, attenuated fibrosis progression, and promoted neovascularization of the ischemic myocardium. The beneficial effects exerted by the EMG-ATDPC and the absence of identified adverse side effects should facilitate its clinical translation as a novel MI therapy in humans. |