Title:
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Biodegradable FeMnSi sputter-coated macroporous polypropylene membranes for the sustained release of drugs
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Author:
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Fornell Beringues, Jordina; Soriano Martín, Jorge; Guerrero, Miguel; Sirvent, Juan de Dios; Ferran Marqués, Marta; Ibáñez, Elena; Barrios, Leonardo; Baró, M. D..; Suriñach, Santiago; Nogués, C. (Carme); Sort Viñas, Jordi; Pellicer Vilà, Eva Maria
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Abstract:
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Pure Fe and FeMnSi thin films were sputtered on macroporous polypropylene (PP) membranes with the aim to obtain biocompatible, biodegradable and, eventually, magnetically-steerable platforms. Room-temperature ferromagnetic response was observed in both Fe- and FeMnSi-coated membranes. Good cell viability was observed in both cases by means of cytotoxicity studies, though the FeMnSi-coated membranes showed higher biodegradability than the Fe-coated ones. Various strategies to functionalize the porous platforms with transferrin-Alexa Fluor 488 (Tf-AF488) molecules were tested to determine an optimal balance between the functionalization yield and the cargo release. The distribution of Tf-AF488 within the FeMnSi-coated PP membranes, as well as its release and uptake by cells, was studied by confocal laser scanning microscopy. A homogeneous distribution of the drug within the membrane skeleton and its sustained release was achieved after three consecutive impregnations followed by the addition of a layer made of gelatin and maltodextrin, which prevented exceedingly fast release. The here-prepared organic-inorganic macroporous membranes could find applications as fixed or magnetically-steerable drug delivery platforms. |
Subject(s):
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-Biodegradable material -Porous membrane -Drug delivery -Hybrid material |
Rights:
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open access
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https://creativecommons.org/licenses/by/3.0/ |
Document type:
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Article |
Published by:
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Share:
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Uri:
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https://ddd.uab.cat/record/181464
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