dc.contributor.author |
Santacana, Martí |
dc.contributor.author |
Arias, Barbara |
dc.contributor.author |
Mitjans, Marina |
dc.contributor.author |
Bonillo Martín, Albert |
dc.contributor.author |
Montoro, María |
dc.contributor.author |
Rosado, Sílvia |
dc.contributor.author |
Guillamat, Roser |
dc.contributor.author |
Vallès, Vicenç |
dc.contributor.author |
Pérez Solà, Víctor |
dc.contributor.author |
Forero, Carlos G. |
dc.contributor.author |
Fullana, Miguel |
dc.date |
2016 |
dc.identifier |
https://ddd.uab.cat/record/170650 |
dc.identifier |
urn:10.1371/journal.pone.0158224 |
dc.identifier |
urn:oai:ddd.uab.cat:170650 |
dc.identifier |
urn:pmid:27355213 |
dc.identifier |
urn:recercauab:ARE-82808 |
dc.identifier |
urn:scopus_id:84977631658 |
dc.identifier |
urn:wos_id:000378859400040 |
dc.identifier |
urn:altmetric_id:9138529 |
dc.identifier |
urn:oai:egreta.uab.cat:publications/882f2dec-a89e-49e9-9134-547d66d159fc |
dc.identifier |
urn:pmc-uid:4927091 |
dc.identifier |
urn:pmcid:PMC4927091 |
dc.identifier |
urn:oai:pubmedcentral.nih.gov:4927091 |
dc.format |
application/pdf |
dc.format |
application/pdf |
dc.language |
eng |
dc.publisher |
|
dc.relation |
PloS one ; Vol. 11, Num. 6 (June 2016), p. 1-14 |
dc.rights |
open access |
dc.rights |
Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original. |
dc.rights |
https://creativecommons.org/licenses/by/4.0/ |
dc.subject |
Child abuse |
dc.subject |
Human genetics |
dc.subject |
Anxiety disorders |
dc.subject |
Drug therapy |
dc.subject |
Genetic polymorphism |
dc.subject |
Anxiety |
dc.subject |
Panic disorder |
dc.subject |
Epigenetics |
dc.title |
Predicting Response Trajectories during Cognitive-Behavioural Therapy for Panic Disorder : No Association with the BDNF Gene or Childhood Maltreatment |
dc.type |
Article |
dc.description.abstract |
Background: Anxiety disorders are highly prevalent and result in low quality of life and a high social and economic cost. The efficacy of cognitive-behavioural therapy (CBT) for anxiety disorders is well established, but a substantial proportion of patients do not respond to this treatment. Understanding which genetic and environmental factors are responsible for this differential response to treatment is a key step towards "personalized medicine". Based on previous research, our objective was to test whether the BDNF Val66Met polymorphism and/or childhood maltreatment are associated with response trajectories during exposure-based CBT for panic disorder (PD). Method: We used Growth Mixture Modeling to identify latent classes of change (response trajectories) in patients with PD (N = 97) who underwent group manualized exposure-based CBT. We conducted logistic regression to investigate the effect on these trajectories of the BDNF Val66Met polymorphism and two different types of childhood maltreatment, abuse and neglect. Results: We identified two response trajectories ("high response" and "low response"), and found that they were not significantly associated with either the genetic (BDNF Val66Met polymorphism) or childhood trauma-related variables of interest, nor with an interaction between these variables. Conclusions: We found no evidence to support an effect of the BDNF gene or childhood trauma-related variables on CBT outcome in PD. Future studies in this field may benefit from looking at other genotypes or using different (e.g. whole-genome) approaches. |