Catchment-wide erosion rates were defined using Be terrestrial cosmogenic nuclides for the Eastern Cordillera of the Colombian Andes to help determine the nature of drainage development and landscape evolution. The Eastern Cordillera, characterized by a smooth axial plateau bordered by steep flanks, has a mean erosion rate of 11 ± 1 mm/ka across the plateau and 70 ± 10 mm/ka on its flanks, with local high rates >400 mm/ka. The erosional contrast between the plateau and its flanks was produced by the increase in the orogen regional slope, derived from the progressive shortening and thickening of the Eastern Cordillera. The erosion rates together with digital topographic analysis show that the drainage network is dynamic and confirms the view that drainage divides in the Eastern Cordillera are migrating towards the interior of the mountain belt resulting in progressive drainage reorganization from longitudinal to transverse-dominated rivers and areal reduction of the Sabana de Bogotá plateau.