The histone code reader PHD finger protein 7 controls sex-linked disparities in gene expression and malignancy in Drosophila

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dc.contributor.author	Molnar, Cristina
dc.contributor.author	Heinen, Jan Peter
dc.contributor.author	Reina, José
dc.contributor.author	Llamazares, Salud
dc.contributor.author	Palumbo, Emilio
dc.contributor.author	Breschi, Alessandra, 1988-
dc.contributor.author	Gay, Marina
dc.contributor.author	Villarreal, Laura
dc.contributor.author	Vilaseca, Marta
dc.contributor.author	Pollarolo, Giulia
dc.contributor.author	González, Cayetano
dc.date	2019
dc.identifier.citation	Molnar C, Heinen JP, Reina J, Llamazares S, Palumbo E, Breschi A, Gay M, Villarreal L, Vilaseca M, Pollarolo G, Gonzalez C. The histone code reader PHD finger protein 7 controls sex-linked disparities in gene expression and malignancy in Drosophila. Sci Adv. 2019; 5(8):eaaw7965. DOI 10.1126/sciadv.aaw7965
dc.identifier.citation	2375-2548
dc.identifier.citation	http://dx.doi.org/10.1126/sciadv.aaw7965
dc.identifier.uri	http://hdl.handle.net/10230/42532
dc.format	application/pdf
dc.language.iso	eng
dc.publisher	American Association for the Advancement of Science (AAAS)
dc.relation	Sci Adv. 2019; 5(8):eaaw7965
dc.relation	info:eu-repo/grantAgreement/EC/FP7/294603
dc.relation	info:eu-repo/grantAgreement/ES/1PE/BFU2015-66304-P
dc.rights	Copyright © 2019 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works. Distributed under a Creative Commons Attribution NonCommercial License 4.0 (CC BY-NC).
dc.rights	info:eu-repo/semantics/openAccess
dc.rights	http://creativecommons.org/licenses/by/4.0/
dc.title	The histone code reader PHD finger protein 7 controls sex-linked disparities in gene expression and malignancy in Drosophila
dc.type	info:eu-repo/semantics/article
dc.type	info:eu-repo/semantics/publishedVersion
dc.description.abstract	The notable male predominance across many human cancer types remains unexplained. Here, we show that Drosophila l(3)mbt brain tumors are more invasive and develop as malignant neoplasms more often in males than in females. By quantitative proteomics, we have identified a signature of proteins that are differentially expressed between male and female tumor samples. Prominent among them is the conserved chromatin reader PHD finger protein 7 (Phf7). We show that Phf7 depletion reduces sex-dependent differences in gene expression and suppresses the enhanced malignant traits of male tumors. Our results identify potential regulators of sex-linked tumor dimorphism and show that these genes may serve as targets to suppress sex-linked malignant traits.
dc.description.abstract	Part of this study was funded by ERC AdG 2011 294603 and BFU2015-66304-P from the MINECO, Spain.

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