Characterizing the spectrum of right ventricular remodelling in response to chronic training

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dc.contributor.author	Sitges, Marta
dc.contributor.author	Merino, Beatriz
dc.contributor.author	Butakoff, Constantine
dc.contributor.author	Sanz de la Garza, Maria
dc.contributor.author	Paré, Carles
dc.contributor.author	Montserrat, Silvia
dc.contributor.author	Vidal, Barbara
dc.contributor.author	Azqueta, Manel
dc.contributor.author	Sarquella-Brugada, Georgia
dc.contributor.author	Gutierrez, Josep Antoni
dc.contributor.author	Canal, Ramon
dc.contributor.author	Brugada, Josep
dc.contributor.author	Bijnens, Bart
dc.date	2017
dc.identifier.citation	Sitges M, Merino B, Butakoff C, Sanz de la Garza M, Paré C, Montserrat S, Vidal B, Azqueta M, Sarquella G, Gutierrez JA, Canal R, Brugada J, Bijnens B. Characterizing the spectrum of right ventricular remodelling in response to chronic training. Int J Cardiovasc Imaging. 2017 March:33(3):331-9. DOI: 10.1007/s10554-016-1014-x
dc.identifier.citation	1569-5794
dc.identifier.citation	http://dx.doi.org/10.1007/s10554-016-1014-x
dc.identifier.uri	http://hdl.handle.net/10230/36998
dc.description.abstract	Background: The significance and spectrum of reduced right ventricular (RV) deformation, reported in endurance athletes, is unclear. Purpose: to comprehensively analyze the cardiac performance at rest of athletes, especially focusing on integrating RV size and deformation to unravel the underlying triggers of this ventricular remodelling. Methods: 100 professional male athletes and 50 sedentary healthy males of similar age were prospectively studied. Conventional echocardiographic parameters of all 4 chambers were obtained, as well as 2D echo-derived strain (2DSE) in the left (LV) and in the RV free wall with separate additional analysis of the RV basal and apical segments. Results: Left and right-sided dimensions were larger in athletes than in controls, but with a disproportionate RA enlargement. RV global strain was lower in sportsmen (-26.8 ± 2.8 vs -28.5 ± 3.4%, p<0.001) due to a decrease in the basal segment (-22.8 ± 3.5 vs -25.8 ± 4.0%, p<0.001) resulting in a marked gradient of deformation from the RV inlet towards the apex. By integrating size, deformation and stroke volume, we observed that the LV working conditions were similar in all sportsmen while a wider variability existed in the RV. Conclusions: Cardiac remodelling in athletes is more pronounced in the right heart cavities with specific regional differences within the right ventricle, but with a wide variability among individuals. The large inter-individual differences, as well as its acute and chronic relevance warrant further investigation.
dc.description.abstract	This work was partially funded by grants from the Fundació Clinic (premio Emili Letang, B. Merino), Generalitat de Catalunya (FI-AGAUR 2014-2017 (RH 040991, M. Sanz), and from the Spanish Society of Cardiology (Fundación Española del Corazón Investigación Clínica 2012), the Spanish Government (Plan Nacional I+D+i, Ministerio de Innovación y Ciencia DEP 2011-2013 (DEP 2010-20565); Intensificación Actividad Investigadora, Instituto de Salud Carlos III (M Sitges; PI11/01709); Plan Nacional I+D, Ministerio de Economia y Competitividad DEP2013-44923-P, TIN2014-52923-R and FEDER.
dc.format	application/pdf
dc.language.iso	eng
dc.publisher	Springer
dc.relation	The International Journal of Cardiovascular Imaging. 2017 March:33(3):331-9.
dc.relation	info:eu-repo/grantAgreement/ES/3PN/DEP2011-2013
dc.relation	info:eu-repo/grantAgreement/ES/3PN/DEP2010-20565
dc.relation	info:eu-repo/grantAgreement/ES/1PE/DEP2013-44923-P
dc.relation	info:eu-repo/grantAgreement/ES/1PE/TIN2014-52923-R
dc.rights	info:eu-repo/semantics/openAccess
dc.rights	© Springer The final publication is available at Springer via http://dx.doi.org/10.1007/s10554-016-1014-x
dc.subject	Right ventricle remodelling
dc.subject	Athlete’s heart
dc.subject	Overload
dc.title	Characterizing the spectrum of right ventricular remodelling in response to chronic training
dc.type	info:eu-repo/semantics/article
dc.type	info:eu-repo/semantics/acceptedVersion

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