Giant tortoise genomes provide insights into longevity and age-related disease

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dc.contributor.author	Quesada, Víctor
dc.contributor.author	Kuderna, Lukas F.K.
dc.contributor.author	Marquès i Bonet, Tomàs, 1975-
dc.contributor.author	López Otín, Carlos
dc.date	2019
dc.identifier.citation	Quesada V, Freitas-Rodríguez S, Miller J, Pérez-Silva JG, Jiang ZF, Tapia W et al. Giant tortoise genomes provide insights into longevity and age-related disease. Nat Ecol Evol. 2019; 3(1):87-95. DOI 10.1038/s41559-018-0733-x
dc.identifier.citation	2397-334X
dc.identifier.citation	http://dx.doi.org/10.1038/s41559-018-0733-x
dc.identifier.uri	http://hdl.handle.net/10230/36785
dc.format	application/pdf
dc.language.iso	eng
dc.publisher	Nature Research
dc.relation	Nat Ecol Evol. 2019; 3(1):87-95
dc.relation	info:eu-repo/grantAgreement/ES/1PE/BFU2014-55090-P
dc.rights	info:eu-repo/semantics/openAccess
dc.rights	© The Author(s), under exclusive licence to Springer Nature Limited 2018. This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
dc.rights	http://creativecommons.org/licenses/by/4.0/
dc.subject	Comparative genomics
dc.subject	Molecular evolution
dc.title	Giant tortoise genomes provide insights into longevity and age-related disease
dc.type	info:eu-repo/semantics/article
dc.type	info:eu-repo/semantics/publishedVersion
dc.description.abstract	Giant tortoises are among the longest-lived vertebrate animals and, as such, provide an excellent model to study traits like longevity and age-related diseases. However, genomic and molecular evolutionary information on giant tortoises is scarce. Here, we describe a global analysis of the genomes of Lonesome George-the iconic last member of Chelonoidis abingdonii-and the Aldabra giant tortoise (Aldabrachelys gigantea). Comparison of these genomes with those of related species, using both unsupervised and supervised analyses, led us to detect lineage-specific variants affecting DNA repair genes, inflammatory mediators and genes related to cancer development. Our study also hints at specific evolutionary strategies linked to increased lifespan, and expands our understanding of the genomic determinants of ageing. These new genome sequences also provide important resources to help the efforts for restoration of giant tortoise populations.
dc.description.abstract	We thank Banco Santander for funding a short stay of S.F.-R. and D.C.-I. at Yale University. V.Q. is supported by grants from the Principado de Asturias and Ministerio de Economía y Competitividad, including FEDER funding. L.F.K.K. is supported by an FPI fellowship associated with BFU2014-55090-P (FEDER). T.M.-B. is supported by MINECO BFU2017-86471-P (MINECO/FEDER, UE), an NIH U01 MH106874 grant, the Howard Hughes International Early Career programme, Obra Social ‘La Caixa’ and Secretaria d’Universitats i Recerca, and CERCA Programme del Departament d’Economia i Coneixement de la Generalitat de Catalunya. C.L.-O. is supported by grants from the European Research Council (DeAge; ERC Advanced Grant), Ministerio de Economía y Competitividad, Instituto de Salud Carlos III (RTICC) and Progeria Research Foundation.

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