Title:
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X-inactivation: quantitative predictions of protein interactions in the Xist network
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Author:
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Agostini, Federico, 1985-; Cirillo, Davide; Bolognesi, Benedetta; Tartaglia, Gian Gaetano
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Abstract:
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The transcriptional silencing of one of the female X-chromosomes is a finely regulated process that requires accumulation in cis of the long non-coding RNA X-inactive-specific transcript (Xist) followed by a series of epigenetic modifications. Little is known about the molecular machinery regulating initiation and maintenance of chromosomal silencing. Here, we introduce a new version of our algorithm catRAPID to investigate Xist associations with a number of proteins involved in epigenetic regulation, nuclear scaffolding, transcription and splicing processes. Our method correctly identifies binding regions and affinities of protein interactions, providing a powerful theoretical framework for the study of X-chromosome inactivation and other events mediated by ribonucleoprotein associations. |
Abstract:
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Funding for open access charge: Spanish Ministry of Economy and Competitiveness [SAF2011-26211] |
Subject(s):
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-Algoritmes -Cromosoma X -RNA |
Rights:
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© 2013 Federico Agostini et al. Published by Oxford University Press. This is an Open Access article distributed under the terms of a Creative Commons Attribution License
http://creativecommons.org/licenses/by-nc/3.0/ |
Document type:
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Article Article - Published version |
Published by:
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Oxford University Press
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