Título:
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Capturing Elusive Cobaltacycle Intermediates: A Real-Time Snapshot of the Cp*CoIII-Catalyzed Oxidative Alkyne Annulation
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Autor/a:
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Sanjosé-Orduna, Jesús; Gallego, Daniel; García-Roca, Alèria; Martin, Eddy; Benet-Buchholz, Jordi; Pérez-Temprano, Mónia H.
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Abstract:
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Despite Cp*CoIII catalysts having emerged as a very attractive alternative to noble transition metals for the construction of heterocyclic scaffolds through C−H activation, the structure of the reactive species remains uncertain. Herein, we report the identification and unambiguous characterization of two long-sought cyclometalated Cp*CoIII complexes that have been proposed as key intermediates in C−H functionalization reactions. The addition of MeCN as a stabilizing ligand plays a crucial role, allowing the access to otherwise highly reactive species. Mechanistic investigations demonstrate the intermediacy of these species in oxidative annulations with alkynes, including the direct observation, under catalytic conditions, of a previously elusive post-migratory insertion seven-membered cobaltacycle. |
Fecha de creación:
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2017 |
Materia(s):
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C−H activation cobalt catalysis heterocycles reaction mechanisms structure elucidation |
Derechos:
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© 2017 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim |
Tipo de documento:
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Artículo |
DOI:
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https://dx.doi.org/10.1002/anie.201704744
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Editor:
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Wiley
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Publish at:
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Angewandte Chemie International Edition
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Compartir:
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