Cardiopulmonary coupling indices to assess weaning readiness from mechanical ventilation

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RECERCAT Home > Universitat Internacional de Catalunya > Recerca > Articles > Ciències de la Salut > View document

To access the full text documents, please follow this link: http://hdl.handle.net/20.500.12328/2767

dc.contributor.author	Armañac-Julián, Pablo
dc.contributor.author	Hernando, David
dc.contributor.author	Lázaro, Jesús
dc.contributor.author	De Haro, Candelaria
dc.contributor.author	Magrans, Rudys
dc.contributor.author	Morales, John
dc.contributor.author	Moeyersons, Jonathan
dc.contributor.author	Sarlabous, Leonardo
dc.contributor.author	López-Aguilar, Josefina
dc.contributor.author	Subirà Cuyàs, Carles
dc.contributor.author	Fernández, Rafael
dc.contributor.author	Orini, Michele
dc.contributor.author	Laguna, Pablo
dc.contributor.author	Varon, Carolina
dc.contributor.author	Gil, Eduardo
dc.contributor.author	Bailón, Raquel
dc.contributor.author	Blanch, Lluís
dc.date	2021-09-08T15:20:48Z
dc.date	2021-09-08T15:20:48Z
dc.date	2021
dc.identifier	Armañac-Julián, Pablo; Hernando, David; Lázaro, Jesús [et al.]. Cardiopulmonary coupling indices to assess weaning readiness from mechanical ventilation. Scientific Reports, 2021, 11, 16014. Disponible en: <https://www.nature.com/articles/s41598-021-95282-2>. Fecha de acceso: 8 sep. 2021. DOI: 10.1038/s41598-021-95282-2
dc.identifier	2045-2322
dc.identifier	http://hdl.handle.net/20.500.12328/2767
dc.identifier	https://dx.doi.org/10.1038/s41598-021-95282-2
dc.identifier.uri	http://hdl.handle.net/20.500.12328/2767
dc.description	The ideal moment to withdraw respiratory supply of patients under Mechanical Ventilation at Intensive Care Units (ICU), is not easy to be determined for clinicians. Although the Spontaneous Breathing Trial (SBT) provides a measure of the patients’ readiness, there is still around 15–20% of predictive failure rate. This work is a proof of concept focused on adding new value to the prediction of the weaning outcome. Heart Rate Variability (HRV) and Cardiopulmonary Coupling (CPC) methods are evaluated as new complementary estimates to assess weaning readiness. The CPC is related to how the mechanisms regulating respiration and cardiac pumping are working simultaneously, and it is defined from HRV in combination with respiratory information. Three different techniques are used to estimate the CPC, including Time-Frequency Coherence, Dynamic Mutual Information and Orthogonal Subspace Projections. The cohort study includes 22 patients in pressure support ventilation, ready to undergo the SBT, analysed in the 24 h previous to the SBT. Of these, 13 had a successful weaning and 9 failed the SBT or needed reintubation –being both considered as failed weaning. Results illustrate that traditional variables such as heart rate, respiratory frequency, and the parameters derived from HRV do not differ in patients with successful or failed weaning. Results revealed that HRV parameters can vary considerably depending on the time at which they are measured. This fact could be attributed to circadian rhythms, having a strong influence on HRV values. On the contrary, significant statistical differences are found in the proposed CPC parameters when comparing the values of the two groups, and throughout the whole recordings. In addition, differences are greater at night, probably because patients with failed weaning might be experiencing more respiratory episodes, e.g. apneas during the night, which is directly related to a reduced respiratory sinus arrhythmia. Therefore, results suggest that the traditional measures could be used in combination with the proposed CPC biomarkers to improve weaning readiness.
dc.format	14
dc.format	application/pdf
dc.language	eng
dc.publisher	Springer Nature
dc.relation	Scientific Reports
dc.relation	11;
dc.rights	This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.
dc.rights	https://creativecommons.org/licenses/by/4.0/
dc.rights	info:eu-repo/semantics/openAccess
dc.subject	Enginyeria biomèdica
dc.subject	Flux de sang
dc.subject	Marcadors predictius
dc.subject	Respiració
dc.subject	Dades científiques
dc.subject	Ingeniería Biomédica
dc.subject	Flujo de sangre
dc.subject	Marcadores predictivos
dc.subject	Respiración
dc.subject	Datos científicos
dc.subject	Biomedical engineering
dc.subject	Blood flow
dc.subject	Predictive markers
dc.subject	Respiration
dc.subject	Scientific data
dc.subject	61
dc.title	Cardiopulmonary coupling indices to assess weaning readiness from mechanical ventilation
dc.type	info:eu-repo/semantics/article
dc.type	info:eu-repo/semantics/publishedVersion

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