Increased infammation, oxidative stress and mitochondrial respiration in brown adipose tissue from obese mice

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RECERCAT Home > Universitat Internacional de Catalunya > Recerca > Articles > Ciències de la Salut > View document

To access the full text documents, please follow this link: http://hdl.handle.net/20.500.12328/1392

dc.contributor.author	Alcalá, Martín
dc.contributor.author	Calderón-Domínguez, María
dc.contributor.author	Bustos, Eduviges
dc.contributor.author	Ramos, Pilar
dc.contributor.author	Casals i Farré, Núria
dc.contributor.author	Serra, Dolors
dc.contributor.author	Viana, Marta
dc.contributor.author	Herrero Rodríguez, Laura
dc.date	2019-12-15T17:56:12Z
dc.date	2019-12-15T17:56:12Z
dc.date	2017-11-22
dc.identifier	Alcalá, Martín; Calderon-Dominguez, María; Bustos, Eduviges [et al.]. Increased inflammation, oxidative stress and mitochondrial respiration in brown adipose tissue from obese mice. Scientific Reports, 2017, vol. 7, 16082, p. 1-12. Disponible en: <https://www.nature.com/articles/s41598-017-16463-6#article-info>. Fecha de acceso: 15 dic. 2019. DOI: 10.1038/s41598-017-16463-6.
dc.identifier	2045-2322
dc.identifier	https://dx.doi.org/10.1038/s41598-017-16463-6
dc.identifier.uri	http://hdl.handle.net/20.500.12328/1392
dc.description	Obesity is associated with severe metabolic diseases such as type 2 diabetes, insulin resistance, cardiovascular disease and some forms of cancer. The pathophysiology of obesity-induced metabolic diseases has been strongly related to white adipose tissue (WAT) dysfunction through several mechanisms such as fibrosis, apoptosis, inflammation, ER and oxidative stress. However, little is known of whether these processes are also present in brown adipose tissue (BAT) during obesity, and the potential consequences on mitochondrial activity. Here we characterized the BAT of obese and hyperglycemic mice treated with a high-fat diet (HFD) for 20 weeks. The hypertrophic BAT from obese mice showed no signs of fibrosis nor apoptosis, but higher levels of inflammation, ER stress, ROS generation and antioxidant enzyme activity than the lean counterparts. The response was attenuated compared with obesity-induced WAT derangements, which suggests that BAT is more resistant to the obesity-induced insult. In fact, mitochondrial respiration in BAT from obese mice was enhanced, with a 2-fold increase in basal oxygen consumption, through the upregulation of complex III of the electron transport chain and UCP1. Altogether, our results show that obesity is accompanied by an increase in BAT mitochondrial activity, inflammation and oxidative damage.
dc.format	12
dc.format	application/pdf
dc.language	eng
dc.publisher	Springer Nature
dc.relation	Scientific Reports
dc.relation	7;
dc.relation	info:eu-repo/grantAgreement/ES/1PE/SAF2014-56671R
dc.relation	info:eu-repo/grantAgreement/ES/1PE/SAF2013-45887-R
dc.relation	info:eu-repo/grantAgreement/ES/1PE/SAF2014-52223-C2-1-R
dc.relation	info:eu-repo/grantAgreement/ES/1PE/SAF2014-52223-C2-2-R
dc.rights	This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
dc.rights	http://creativecommons.org/licenses/by/4.0/
dc.subject	Lípids
dc.subject	61
dc.title	Increased infammation, oxidative stress and mitochondrial respiration in brown adipose tissue from obese mice
dc.type	info:eu-repo/semantics/article
dc.type	info:eu-repo/semantics/acceptedVersion

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