Título:
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Brain region volumes and their relationship with disability progression and cognitive function in primary progressive multiple sclerosis
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Autor/a:
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Pérez-Miralles, Francisco; Prefasi, Daniel; García-Merino, Antonio; Ara Callizo, José Ramón; Izquierdo, Guillermo; Meca-Lallana, Virginia; Ramió-Torrentà, Lluís
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Otros autores:
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Institut Català de la Salut; [Pérez-Miralles FC] Neuroimmunology Unit, Department of Neurology, Hospital Universitari i Politècnic La Fe, Valencia, Spain. [Prefasi D] Department of Medical, Roche Farma S.A, Madrid, Spain. [García-Merino A] Department of Neurology, Hospital Universitario Puerta de Hierro, Majadahonda, Spain. [Ara JR] Department of Neurology, Hospital Universitario Miguel Servet, Zaragoza, Spain.[Izquierdo G] Department of Neurology, Hospital Universitario Virgen Macarena, Seville, Spain. [Meca-Lallana V] Department of Neurology, Hospital Universitario La Princesa, Madrid, Spain. [Ramió-Torrentà L] Unitat de Neuroimmunologia i Esclerosi Múltiple, Departament de Neurologia, Hospital Universitari de Girona Dr. Josep Trueta, Institut Català de la Salut (ICS), Girona, Spain. Institut d’Assistència Sanitària, Salt, Spain. Institut d’Investigació Biomèdica de Girona (IDIBGI), Salt, Spain. Departament de Ciències Mèdiques, Facultat de Medicina, Universitat de Girona, Girona, Spain; Hospital Universitari de Girona Dr Josep Trueta |
Abstract:
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Función cognitiva; Imagen por resonancia magnética; Esclerosis múltiple primaria progresiva |
Abstract:
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Cognitive function; Magnetic resonance imaging; Primary progressive multiple sclerosis |
Abstract:
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Funció cognitiva; Imatge per ressonància magnètica; Esclerosi múltiple primària progressiva |
Abstract:
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Background and purpose: Evidence on regional changes resulting from neurodegenerative processes underlying primary progressive multiple sclerosis (PPMS) is still limited. We assessed brain region volumes and their relationship with disability progression and cognitive function in PPMS patients.
Methods: This was an MRI analysis of 43 patients from the prospective Understanding Primary Progressive Multiple Sclerosis (UPPMS) cohort study. MRI scans were performed within 3 months before enrollment and at month 12.
Results: Gray matter volume of declive and white matter volumes adjacent to left straight gyrus, right calcarine sulcus, and right inferior occipital gyrus significantly decreased from baseline to month 12. Baseline white matter volumes adjacent to right amygdala and left cuneus significantly differed between patients with and without disability progression, as well as baseline gray matter volumes of left cuneus, right parahippocampal gyrus, right insula, left superior frontal gyrus, declive, right inferior temporal gyrus, right superior temporal gyrus (pole), and right calcarine sulcus. Baseline gray matter volumes of right cuneus and right superior temporal gyrus positively correlated with 12-month Selective Reminding Test and Word List Generation performance, respectively. Gray matter changes in right superior semilunar lobe and white matter adjacent to left declive and right cerebellar tonsil also positively correlated with Word List Generation scores, while white matter change in left inferior semilunar lobe positively correlated with Symbol Digit Modalities Test performance after 12 months.
Conclusions: White and gray matter volumes of specific brain regions could predict disability progression and cognitive performance of PPMS patients after one year. |
Abstract:
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Roche Farma S.A.. Grant Number: ML39253 |
Materia(s):
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-Imatgeria per ressonància magnètica -Cervell -Esclerosi múltiple -ANALYTICAL, DIAGNOSTIC AND THERAPEUTIC TECHNIQUES, AND EQUIPMENT::Diagnosis::Diagnostic Techniques and Procedures::Diagnostic Imaging::Tomography::Magnetic Resonance Imaging -PSYCHIATRY AND PSYCHOLOGY::Psychological Phenomena::Mental Processes::Cognition -DISEASES::Nervous System Diseases::Autoimmune Diseases of the Nervous System::Demyelinating Autoimmune Diseases, CNS::Multiple Sclerosis::Multiple Sclerosis, Chronic Progressive -ENFERMEDADES::enfermedades del sistema nervioso::enfermedades autoinmunitarias del sistema nervioso::enfermedades autoinmunes desmielinizantes del SNC::esclerosis múltiple::esclerosis múltiple crónica progresiva -TÉCNICAS Y EQUIPOS ANALÍTICOS, DIAGNÓSTICOS Y TERAPÉUTICOS::diagnóstico::técnicas y procedimientos diagnósticos::diagnóstico por imagen::tomografía::imagen por resonancia magnética -PSIQUIATRÍA Y PSICOLOGÍA::fenómenos psicológicos::procesos mentales::cognición |
Derechos:
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Attribution 4.0 International
http://creativecommons.org/licenses/by/4.0/
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Tipo de documento:
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Artículo Artículo - Versión publicada |
Editor:
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Wiley
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