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Title:
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Correlation between previous antibiotic exposure and COVID-19 severity: a population-based cohort study
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Author:
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Llor, Carla; Ouchi, Dan; Giner-Soriano, Maria; Garcia-Sangenis, Ana; Bjerrum, Lars; Morros, Rosa
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Other authors:
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[Llor C] Fundació Institut Universitari per la Recerca a l’Atenció Primària de Salut Jordi Gol i Gurina (IDIAPJGol), Barcelona, Spain. Department of Public Health, General Practice, University of Southern Denmark, Odense, Denmark. [Ouchi D, Giner-Soriano M] Fundació Institut Universitari per la Recerca a l’Atenció Primària de Salut Jordi Gol i Gurina (IDIAPJGol), Barcelona, Spain. Universitat Autònoma de Barcelona, Bellaterra, Spain. [García-Sangenís A] Fundació Institut Universitari per la Recerca a l’Atenció Primària de Salut Jordi Gol i Gurina (IDIAPJGol), Barcelona, Spain. [Bjerrum L] Section and Research Unit of General Practice, Department of Public Health, University of Copenhagen, Copenhagen, Denmark. [Morros R] Fundació Institut Universitari per la Recerca a l’Atenció Primària de Salut Jordi Gol i Gurina (IDIAPJGol), Barcelona, Spain. Departament de Farmacologia, Terapèutica i Toxicologia, Universitat Autònoma de Barcelona, Bellaterra, Spain. Plataforma SCReN, IICEC IDIAP Jordi Gol, Barcelona, Spain; IDIAP Jordi Gol |
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Abstract:
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Resistencia a los medicamentos; Atención primaria; COVID-19; Agentes antibacterianos |
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Abstract:
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Drug resistance; Primary health care; COVID-19; Anti-bacterial agents |
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Abstract:
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Resistència als fàrmacs; Atenció primària; COVID-19; Agents antibacterians |
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Abstract:
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We examined the correlation between previous antibiotic exposure and COVID-19 severity using a population-based observational matched cohort study with patient level data obtained for more than 5.8 million people registered in SIDIAP in Catalonia, Spain. We included all patients newly diagnosed with COVID-19 from March to June 2020 and identified all their antibiotic prescriptions in the previous two years. We used a composite severity endpoint, including pneumonia, hospital admission and death due to COVID-19. We examined the influence of high antibiotic exposure (>4 regimens), exposure to highest priority critically important antimicrobials (HPCIA) and recent exposure. Potential confounders were adjusted by logistic regression. A total of 280,679 patients were diagnosed with COVID-19, 146,656 of whom were exposed to at least one antibiotic course (52.3%) during the preceding two years. A total of 25,222 presented severe COVID-19 infection (9%), and the risk of severity was highest among those exposed to antibiotics (OR 1.12; 95% CI: 1.04–1.21). Among all individuals exposed to antibiotics, high, recent and exposure to HPCIAs were correlated with increased COVID severity (OR 1.19; 95% CI: 1.14–1.26; 1.41; 95% CI: 1.36–1.46; and 1.35; 95% CI: 1.30–1.40, respectively). Our findings confirm a significant correlation between previous antibiotic exposure and increased severity of COVID-19 disease. |
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Subject(s):
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-COVID-19 (Malaltia)
-Antibiòtics
-DISEASES::Virus Diseases::RNA Virus Infections::Nidovirales Infections::Coronaviridae Infections::Coronavirus Infections
-CHEMICALS AND DRUGS::Chemical Actions and Uses::Pharmacologic Actions::Therapeutic Uses::Anti-Infective Agents::Anti-Bacterial Agents
-DISCIPLINES AND OCCUPATIONS::Natural Science Disciplines::Mathematics::Statistics as Topic::Correlation of Data
-ENFERMEDADES::virosis::infecciones por virus ARN::infecciones por Nidovirales::infecciones por Coronaviridae::infecciones por Coronavirus
-COMPUESTOS QUÍMICOS Y DROGAS::acciones y usos químicos::acciones farmacológicas::usos terapéuticos::antiinfecciosos::antibacterianos
-DISCIPLINAS Y OCUPACIONES::disciplinas de las ciencias naturales::matemáticas::estadística como asunto::correlación de datos |
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Rights:
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Attribution-NonCommercial-NoDerivatives 4.0 International
http://creativecommons.org/licenses/by-nc-nd/4.0/
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Document type:
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Article
Article - Published version |
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Published by:
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MDPI
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