Critical role of interleukin (IL)-17 in inflammatory and immune disorders: An updated review of the evidence focusing in controversies

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RECERCAT Home > Sistema de Salut de Catalunya > Centre d'Esclerosi Múltiple de Catalunya – CEMCAT > Articles científics - CEMCAT > View document

To access the full text documents, please follow this link: http://hdl.handle.net/11351/6373

Title:	Critical role of interleukin (IL)-17 in inflammatory and immune disorders: An updated review of the evidence focusing in controversies
Author:	Ruiz de Morales, José María G.; Puig, Lluís; Daudén, Esteban; Cañete, Juan D.; Pablos, José Luis; Olveira Martín, Antonio; Montalban Gairín, Xavier; Borruel Sainz, Natalia; Orti Pascual, Guillem
Other authors:	Institut Català de la Salut; [Ruiz de Morales JMG] Inmunology Unit, Complejo Asistencial Universitario e Instituto de Biomedicina Universidad de León (IBIOMED), León, Spain. [Puig L] Department of Dermatology, Hospital de la Santa Creu i Sant Pau, Barcelona, Spain. Facultat de Medicina, Universitat Autònoma de Barcelona, Bellaterra, Spain. [Daudén E] Dermatology Department, Instituto de Investigación Sanitaria La Princesa (IIS-IP), Hospital Universitario de la Princesa, Madrid, Spain. [Cañete JD] Arthritis Unit, Rheumatology Dpt.,Hospital Clinic and IDIBAPS, Barcelona, Spain. [Pablos JL] Rheumatology Department, Hospital 12 de Octubre, Instituto de Investigación Hospital 12 de Octubre, Madrid, Spain. [Martín AO] Gastroenterology Department, La Paz Universitary Hospital, Madrid, Spain. [Montalbán X] Servei de Neurologia/Neuroimmunologia, Centre d'Esclerosi Múltiple de Catalunya (CEMCAT), Barcelona, Spain. Vall d'Hebron Institut de Recerca (VHIR), Barcelona, Spain. Vall d'Hebron Hospital Universitari, Barcelona, Spain. [Borruel N] Unitat d’Atenció Crohn-Colitis, Unitat de Recerca en Aparell Digestiu, Vall d'Hebron Hospital Universitari, Barcelona, Spain. [Ortí G] Servei d’Hematologia, Vall d'Hebron Hospital Universitari, Barcelona, Spain. Vall d'Hebron Institute of Oncology (VHIO), Barcelona, Spain; Hospital Universitari Vall d'Hebron
Abstract:	Medicaments biològics; Inflamació; Psoriasi
Abstract:	Biological drugs; Inflammation; Psoriasis
Abstract:	Medicamentos biológicos; Inflamación; Psoriasis
Abstract:	Interleukin 17 (IL-17) is a proinflammatory cytokine that has been the focus of intensive research because of its crucial role in the pathogenesis of different diseases across many medical specialties. In this context, the present review in which a panel of 13 experts in immunology, dermatology, rheumatology, neurology, hematology, infectious diseases, hepatology, cardiology, ophthalmology and oncology have been involved, puts in common the mechanisms through which IL-17 is considered a molecular target for the development of novel biological therapies in these different fields. A comprehensive review of the literature and analysis of the most outstanding evidence have provided the basis for discussing the most relevant data related to IL-17A blocking agents for the treatment of different disorders, such as psoriasis, psoriatic arthritis, rheumatoid arthritis, ankylosing spondylitis, cardiovascular disorders, non alcoholic fatty liver disease, multiple sclerosis, inflammatory bowel disease, uveitis, hematological and solid cancer. Current controversies are presented giving an opening line for future research.
Abstract:	This work was supported by Novartis Pharmaceuticals Spain.
Subject(s):	-Psoriasi -Citocines - Immunologia -DISEASES::Skin and Connective Tissue Diseases::Skin Diseases::Skin Diseases, Papulosquamous::Psoriasis -CHEMICALS AND DRUGS::Biological Factors::Intercellular Signaling Peptides and Proteins::Cytokines -Other subheadings::Other subheadings::Other subheadings::/immunology -ENFERMEDADES::enfermedades de la piel y tejido conjuntivo::enfermedades de la piel::enfermedades cutáneas papuloescamosas::psoriasis -COMPUESTOS QUÍMICOS Y DROGAS::factores biológicos::péptidos y proteínas de señalización intercelular::citocinas -Otros calificadores::Otros calificadores::Otros calificadores::/inmunología
Rights:	Attribution 4.0 International http://creativecommons.org/licenses/by/4.0/
Document type:	Article Article - Published version
Published by:	Elsevier
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