Título:
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Effectiveness, safety and costs of thromboembolic prevention in patients with non-valvular atrial fibrillation: phase I ESC-FA protocol study and baseline characteristics of a cohort from a primary care electronic database
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Autor/a:
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Giner-Soriano, Maria; Vedia-Urgell, Cristina; Roso-Llorach, Albert; Morros, Rosa; Capellà, Dolors; Castells Cervelló, Xavier; Ferreira González, Ignacio; Troncoso-Mariño, Amelia; Diogène Fadini, Eduard; Elorza Ricart, Josep Maria; Casajuana-Closas, Marc; Bolíbar-Ribas, Bonaventura; Violán-Fors, Concepción
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Otros autores:
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Institut Català de la Salut; [Giner-Soriano M, Roso-Llorach A, Morros R, Casajuana M, Bolíbar B, Violan C] Institut Universitari d'Investgació en Atenció Primària Jordi Gol (IDIAP Jordi Gol), Barcelona, Spain. Universitat Autònoma de Barcelona (UAB), Bellaterra, Spain. [Vedia Urgell C] Unitat de farmàcia, Servei d'Atenció Primària Barcelonès Nord i Maresme, Institut Català de la Salut, Badalona, Spain. Universitat Autònoma de Barcelona (UAB), Bellaterra, Spain. [Capellà D, Castells X] Translab Research Group, Unitat de Farmacologia Clínica, Departament de Ciències Mèdiques, Facultat de Medicina, UdG, Girona, Spain. [Ferreira-González I] Unidad de Epidemiología del Servicio de Cardiología, Hospital Vall d'Hebron y CIBER de Epidemiología y Salud Pública (CIBERESP), Barcelona, Spain. [Troncoso-Mariño A] Unitat de Coordinació i Estratègia del Medicament, Institut Català de la Salut, Barcelona, Spain. [Diogène E] Servei de Farmacologia, Hospital Vall d'Hebron, Barcelona, Spain. [Elorza JM] System for the Improvement of Research in Primary Care (SIDIAP), Barcelona, Spain.; IDIAP Jordi Gol |
Abstract:
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atrial fibrillation, electronic health records, anticoagulants, platelet aggregation inhibitors, stroke, bleeding |
Abstract:
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Purpose
Atrial fibrillation is the most common arrhythmia. Its management aims to reduce symptoms and to prevent complications through rate and rhythm control, management of concomitant cardiac diseases and prevention of related complications, mainly stroke.
The main objective of ESC-FA study is to analyse the drugs used for the management of the disease in real-use conditions, in particular antithrombotic agents for stroke prevention. The aim of this work is to present the study protocol of Phase I of the ESC-FA study and the baseline characteristics of newly diagnosed patients with atrial fibrillation in Catalonia, Spain.
Participants
The data source is SIDIAP database. The population included are all patients with non-valvular atrial fibrillation diagnosis registered in the electronic health records during 2007-2012.
Findings to date
A total of 22,585 patients with non-valvular atrial fibrillation were included in the baseline description. Their mean age was 72.8 years and 51.6% were men. The most commonly prescribed antithrombotics were vitamin K antagonists (40.1% of patients) and platelet aggregation inhibitors (32.9%); 25.3% had not been prescribed antithrombotic treatment. Age, gender, comorbidities and comedication at baseline were similar to those reported for previous studies.
Future plans
The next steps in the ESC-FA study will be assessing effectiveness and safety of antithrombotic treatments, analysing stroke events and bleeding episodes’ rates in our patients (rest of phase I), describing the current management of the disease and its costs in our setting, and assessing how the introduction of new oral anticoagulants changes the stroke prevention in non-valvular atrial fibrillation. |
Materia(s):
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-Atenció primària - Catalunya - Investigació -Fibril·lació auricular - Tractament -Anticoagulants (Medicina) -DISEASES::Cardiovascular Diseases::Heart Diseases::Arrhythmias, Cardiac::Atrial Fibrillation -ANALYTICAL, DIAGNOSTIC AND THERAPEUTIC TECHNIQUES AND EQUIPMENT::Investigative Techniques::Epidemiologic Methods::Data Collection::Records as Topic::Medical Records::Health Records, Personal::Electronic Health Records -CHEMICALS AND DRUGS::Chemical Actions and Uses::Pharmacologic Actions::Therapeutic Uses::Hematologic Agents::Anticoagulants -ENFERMEDADES::enfermedades cardiovasculares::enfermedades cardíacas::arritmias cardíacas::fibrilación atrial -TÉCNICAS Y EQUIPOS ANALÍTICOS, DIAGNÓSTICOS Y TERAPÉUTICOS::técnicas de investigación::métodos epidemiológicos::recopilación de datos::registros::registros médicos::sistemas informatizados de historias clínicas::historias clínicas electrónicas -COMPUESTOS QUÍMICOS Y DROGAS::acciones y usos químicos::acciones farmacológicas::usos terapéuticos::fármacos hematológicos::anticoagulantes |
Derechos:
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Atribución-NoComercial-SinDerivadas 3.0 España
http://creativecommons.org/licenses/by-nc-nd/3.0/es/
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Tipo de documento:
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Artículo Artículo - Versión publicada |
Editor:
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BMJ Open
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