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Título:	Integrative Multidimensional Methods applied to Molecular Classification in Muscle Invasive Bladder Cancer
Autor/a:	Gonzalez Alvaredo, Sonia
Otros autores:	Universitat de Vic - Universitat Central de Catalunya. Facultat de Ciències i Tecnologia; Universitat de Vic - Universitat Central de Catalunya. Màster Universitari en Anàlisi de Dades Òmiques
Notas:	Curs 2016-2017 To move toward a molecular taxonomy, we investigated three genome-wide platform data, integrated as an unified categorical code called gene configuration. We performed a multidimensional analysis of the gene configuration on known protein coding genes for 218 patients of muscle invasive bladder cancer, revealing a unified classification into three major subtypes. The classification obtained allow us to describe heterogeneous groups among different ethnic origins. This classification follow mechanistic differences for the different pathways involved in the bladder cancer profiling. A feature selection method based in multiple correspondence analysis allowed to mine the determinant gene configurations involved in the molecular profiling of muscle invasive bladder cancer. Director/a: Enrique Carrillo de Santa Pau Co-director/a: Francisco Real
Materia(s):	-Bufeta -- Càncer -Molècules -- Classificació
Derechos:	Tots els drets reservats
Tipo de documento:	Trabajo fin de máster
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