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Título:
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Growth Performance and Clinicopathological Analyses in Lambs Repetitively Inoculated with Aluminum-Hydroxide Containing Vaccines or Aluminum-Hydroxide Only
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Autor/a:
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Miguel, Ricardo de; Asín, Javier; Rodríguez-Largo, Ana; Echeverría, Irache; Lacasta, Delia; Pinczowski, Pedro; Gimeno, Marina; Molín, Jéssica; Fernández, Antonio; Blas, Ignacio de; Andrés, Damián de; Pérez, Marta; Reina, Ramsés; Luján, Lluís
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Notas:
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Aluminum (Al) hydroxide is an effective adjuvant used in sheep vaccines. However, Al-adjuvants have been implicated as potential contributors to a severe wasting syndrome in sheep—the so-called ovine autoimmune-inflammatory syndrome induced by adjuvants (ASIA syndrome). This work aimed to characterize the effects of the repetitive injection of Al-hydroxide containing products in lambs. Four flocks (Flocks 1–4; n = 21 each) kept under different conditions were studied. Three groups of seven lambs (Vaccine, Adjuvant-only, and Control) were established in each flock. Mild differences in average daily gain and fattening index were observed, indicating a reduced growth performance in Vaccine groups, likely related to short-term episodes of pyrexia and decreased daily intake. Clinical and hematological parameters remained within normal limits. Histology showed no significant differences between groups, although there was a tendency to present a higher frequency of hyperchromatic, shrunken neurons in the lumbar spinal cord in the Adjuvant-only group. Although Al-hydroxide was linked to granulomas at the injection site and behavioral changes in sheep, the results of the present experimental work indicate that injected Al-hydroxide is not enough to fully reproduce the wasting presentation of the ASIA syndrome. Other factors such as sex, breed, age, production system, diet or climate conditions could play a role.
This work was funded by grants from the Spanish Ministry of Economy, Industry and Competitiveness (AGL2013-49137-C3-1-R and AGL2013-49137-C3-2-R), the Ministry of Science, Innovation and Universities (RTI2018-096172-B-C31 and RTI2018-096172-B-C33) and the Recognized Research Groups of Government of Aragón (A17_17R, Animal Health and Reproduction). RdM was a PhD student funded by the Department of Innovation, Research and University of Aragón. JA and ARL were PhD students funded by the Spanish Ministry of Science, Innovation and Universities (formerly Spanish Ministry of Education). IE was a PhD student funded by the Universidad Pública de Navarra. |
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Materia(s):
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-Aluminum-hydroxide
-Aluminum-based adjuvant
-Aluminum-based vaccine
-Growth performance
-Hematology |
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Derechos:
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cc-by, (c) Miguel, Ricardo de et al., 2021
http://creativecommons.org/licenses/by/4.0/
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Tipo de documento:
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Artículo
Artículo - Versión publicada |
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Editor:
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MDPI
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Compartir:
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