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Título:
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Effects of hesperidin in orange juice on blood and pulse pressures in mildly hypertensive individuals: a randomized controlled trial (Citrus study)
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Autor/a:
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Valls, Rosa M.; Pedret, Anna; Calderón-Pérez, Lorena; Llauradó, Elisabet; Pla-Pagà, Laura; Companys, Judit; Moragas, Ana; Martín Luján, Francisco Manuel; Ortega, Yolanda; Giralt, Montserrat; Romeu, Marta; Rubió Piqué, Laura; Mayneris Perxachs, Jordi; Canela, Núria; Puiggròs i Llavinés, Francesc; Caimari, Antoni; Bas, Josep M. del; Arola i Ferrer, Lluís; Solà, Rosa
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Notas:
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Purpose: To assess the sustained and acute effects, as well as the influence of sustained consumption on the acute effects, of orange juice (OJ) with a natural hesperidin content and hesperidin-enriched OJ (EOJ) on blood (BP) and pulse (PP) pressures in pre- and stage-1 hypertensive individuals. Methods: In a randomized, parallel, double-blind, placebo-controlled trial, participants (n = 159) received 500 mL/day of control drink, OJ, or EOJ for 12 weeks. Two dose–response studies were performed at baseline and after 12 weeks. Results: A single EOJ dose (500 mL) reduced systolic BP (SBP) and PP, with greater changes after sustained treatment where a decrease in diastolic BP (DBP) also occurred (P < 0.05). SBP and PP decreased in a dose-dependent manner relative to the hesperidin content of the beverages throughout the 12 weeks (P < 0.05). OJ and EOJ decreased homocysteine levels at 12 weeks versus the control drink (P < 0.05). After 12 weeks of EOJ consumption, four genes related to hypertension (PTX3, NLRP3, NPSR1 and NAMPT) were differentially expressed in peripheral blood mononuclear cells (P < 0.05). Conclusion: Hesperidin in OJ reduces SBP and PP after sustained consumption, and after a single dose, the chronic consumption of EOJ enhances its postprandial effect. Decreases in systemic and transcriptomic biomarkers were concomitant with BP and PP changes. EOJ could be a useful co-adjuvant tool for BP and PP management in pre- and stage-1 hypertensive individuals.
The Florida Department of Citrus, an executive agency of the state of Florida, USA, provided a grant and study drinks to the Eurecat, Centre Tecnològic de Catalunya, Unitat de Nutrició i Salut, Reus, Spain. A.P. has a Torres Quevedo contract (Subprograma Estatal de Incorporación, Plan Estatal de Investigación Científica y Técnica y de Innovación). |
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Materia(s):
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-Orange juice
-Hesperidin
-Blood pressure
-Pulse pressure
-Pre-hypertension |
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Derechos:
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cc-by, (c) Valls, Rosa M. et al., 2020
http://creativecommons.org/licenses/by/4.0/
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Tipo de documento:
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Artículo
Artículo - Versión publicada |
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Editor:
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Springer
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Compartir:
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