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Title:
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Social environment mediates cancer progression in Drosophila
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Author:
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Dawson, Erika H.; Bailly, Tiphaine P. M.; Dos Santos, Julie; Moreno, Céline; Devilliers, Maëlle; Maroni, Brigitte; Sueur, Cédric; Casali, Andreu; Ujvari, Beata; Thomas, Frederic; Montagne, Jacques; Mery, Frederic
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Notes:
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The influence of oncogenic phenomena on the ecology and evolution of animal species is
becoming an important research topic. Similar to host–pathogen interactions, cancer negatively
affects host fitness, which should lead to the selection of host control mechanisms,
including behavioral traits that best minimize the proliferation of malignant cells. Social
behavior is suggested to influence tumor progression. While the ecological benefits of
sociality in gregarious species are widely acknowledged, only limited data are available on the
role of the social environment on cancer progression. Here, we exposed adult Drosophila, with
colorectal-like tumors, to different social environments. We show how subtle variations in
social structure have dramatic effects on the progression of tumor growth. Finally, we reveal
that flies can discriminate between individuals at different stages of tumor development and
selectively choose their social environment accordingly. Our study demonstrates the reciprocal
links between cancer and social interactions and how sociality may impact health and
fitness in animals and its potential implications for disease ecology.
This work was supported by the ANR (Blanc project EVOCAN to F.T. and project DROSONET to F.M. and C.S.), the CNRS (INEE and INSB), Fondation ARC (1555286 to J.M. and F.M.), The French league against Cancer (M27218 to J.M.), IDEEV program (to F.M.), by an International Associated Laboratory Project France/Australia, by the French-Australian Science Innovation Collaboration Program Early Career Fellowship (B.U.), by André Hoffmann (Fondation MAVA), Fyssen Foundation (to F.M. and E.H. D.) and the French Government (fellowship 2015–155 to M.D.). |
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Rights:
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cc-by (c) Erika H. Dawson et al., 2018
http://creativecommons.org/licenses/by/4.0/
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Document type:
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Article
Article - Published version |
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Published by:
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Springer Nature
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