| dc.contributor.author |
Prats, Claudia |
| dc.contributor.author |
Arias Sampériz, Bárbara |
| dc.contributor.author |
Ortet i Fabregat, Generós |
| dc.contributor.author |
Ibáñez Ribes, Manuel Ignacio |
| dc.contributor.author |
Moya Higueras, Jorge |
| dc.contributor.author |
Pomarol-Clotet, Edith |
| dc.contributor.author |
Fañanás Saura, Lourdes |
| dc.contributor.author |
Fatjó-Vilas, Mar |
| dc.date |
2018-09-25T10:37:03Z |
| dc.date |
2018-09-25T10:37:03Z |
| dc.date |
2017 |
| dc.date |
2018-09-25T10:37:05Z |
| dc.identifier |
0165-0327 |
| dc.identifier |
http://hdl.handle.net/10459.1/64765 |
| dc.identifier |
https://doi.org/10.1016/j.jad.2016.11.017 |
| dc.identifier.uri |
http://hdl.handle.net/10459.1/64765 |
| dc.description |
Background: Neuritin-1 is a neurotrophic factor involved in synaptic plasticity that has been associated with depressive disorders, schizophrenia and cognitive performance. The study of genotype-phenotype relationships in healthy individuals is a useful framework to investigate the etiology of brain dysfunctions. We therefore aimed to investigate in a non-clinical sample whether NRN1 gene contributes to the psychopathological profile, with a particular focus on the clinical dimensions previously related to the NRN1 gene (i.e. depressive and psychotic). Furthermore, we aimed to analyze: i) the role of NRN1 on executive functions, ii) whether the association between either NRN1-psychopathological profile or NRN1-cognitive performance is moderated by the BDNF gene. Methods: The sample is comprised of 410 non-clinical subjects who filled in the self-reported Brief Symptom Inventory (BSI) and were assessed for executive performance (Verbal Fluency, Wisconsin Card Sorting Test (WCST) and Letter-Number subscale (WAIS-III)). Genotyping included nine SNPs in NRN1 and one in BDNF. Results: i) GG homozygotes (rs1475157-NRN1) showed higher scores on BSI depressive dimension and on total scores compared to A carriers (corrected p-values: 0.0004 and 0.0003, respectively). ii) A linear trend was detected between GG genotype of rs1475157 and a worse cognitive performance in WCST total correct responses (uncorrected p-value: 0.029). iii) Interaction between rs1475157-NRN1 and Val66Met-BDNF was found to modulate depressive symptoms (p=0.001, significant after correction). Limitations: Moderate sample size; replication in a larger sample is needed. Conclusions: NRN1 is associated with depressive symptoms and executive function in a non-clinical sample. Our results also suggest that the role of NRN1 seems to be modulated by BDNF. |
| dc.description |
This study was supported by: i) Intramural Project CIBERSAM (P91E), ii) The Network of European Funding for Neuroscience Research, ERA-NET NEURON (PiM2010ERN-00642), iii) Instituto de Salud Carlos III through the project PI15/01420 (co-funded by European Regional Development Fund /European Social Fund, “Investing in your future”). Thanks to: i) the Comissionat per a Universitats i Recerca del DIUE (2014SGR1636), ii) Universitat de Barcelona and APIF-IBUB grant 2014. |
| dc.format |
application/pdf |
| dc.language |
eng |
| dc.publisher |
Elsevier |
| dc.relation |
Versió preprint del document publicat a: https://doi.org/10.1016/j.jad.2016.11.017 |
| dc.relation |
Journal of Affective Disorders, 2017, vol. 211, p. 92-98 |
| dc.rights |
(c) Elsevier, 2017 |
| dc.rights |
info:eu-repo/semantics/openAccess |
| dc.subject |
Depressive symptoms |
| dc.subject |
Executive function |
| dc.subject |
NRN1 gene |
| dc.subject |
Bdnf val66met |
| dc.subject |
Gene-gene interaction |
| dc.subject |
Depressió psíquica |
| dc.subject |
Malalties mentals |
| dc.subject |
Psicologia genètica |
| dc.subject |
Mental depression |
| dc.subject |
Mental illness |
| dc.subject |
Genetic psychology |
| dc.title |
Role of neurotrophins in depressive symptoms and executive function: association analysis of NRN1 gene and its interaction with BDNF gene in a non-clinical sample |
| dc.type |
info:eu-repo/semantics/article |
| dc.type |
info:eu-repo/semantics/submittedVersion |
