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Title:
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A WUR SNP is associated with European Porcine Reproductive and Respiratory Virus Syndrome resistance and growth performance in pigs
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Author:
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Abella Falcó, Glòria; Pena i Subirà, Ramona Natacha; Nogareda, Carmina; Armengol Gelonch, Ramon; Vidal, Albert; Moradell, Luís; Tarancón, Vicens; Novell, Elena; Estany Illa, Joan; Fraile Sauce, Lorenzo José
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Notes:
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Porcine reproductive and respiratory syndrome (PRRS) causes decreased reproductive performance and respiratory problems in pigs. The goals of the current study were 1) to examine whether individual variation applies to infection with PRRSV European strains and 2) to investigate the association of a single nucleotide polymorphism (SNP) WUR10000125 (WUR) at the interferon-inducible guanylate-binding protein 1 gene (GBP1) with average daily gain (ADG) in PRRSV infected and uninfected pigs. The experimental procedure consisted of two trials in which pigs from negative PRRSV farms were infected with a wild-type (n = 80) or vaccinated with an attenuated European PRRS virus strain (n = 40) and then monitored after infection or vaccination. Viral load and ADG were determined for each pig. In a third trial, the ADG for PRRSV-free pigs was monitored. All pigs were genotyped for WUR at the GBP1 gene (AA and AG genotype were defined). Results indicated that there was individual variation in the viral load from pigs challenged with a wild-type or low virulent European PRRSV strain. Secondly, our data showed that WUR SNP was associated to ADG in vaccinated pigs. Thus, ADG in AG pigs was significantly higher than in AA ones after vaccinating with an attenuated PRRSV strain. However, the reverse happened in a PRRSV-free environment where the AA pigs were those that grew faster. Based on these results, there is a scope for selecting pigs according to their responses to PRRS virus infection with European strains and that WUR SNP may play a role in causing PRRSV resistance.
This study was carried out with the support of the Vall Companys group in Lleida and the Group of Sanejament Porci (GSP, Lleida, Spain). The authors wish to thank specially to Ferran González Romero and Cristina Labella for their collaboration in conducting the field study and technical assistance, respectively. Glòria Abella is an industrial doctorate awarded by the government of Catalonia (No. 2013 DI 027). |
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Subject(s):
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-Variation
-Piglets
-PRRSV
-Genetic resistance |
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Rights:
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cc-by-nc-nd, (c) Elsevier, 2015
http://creativecommons.org/licenses/by-nc-nd/4.0/
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Document type:
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Article
Article - Accepted version |
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Published by:
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Elsevier
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Share:
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