|
Título:
|
High tumor incidence and activation of the PI3K/AKT pathway in transgenic mice define AIB1 as an oncogene
|
|
Autor/a:
|
Torres-Arzayus, Maria I.; Font de Mora, Jaime; Yuan, Jing; Vazquez, Francisca; Bronson, Roderick; Rué i Monné, Montserrat; Sellers, William R.; Brown, Myles
|
|
Notas:
|
The gene encoding AIB1, an estrogen receptor coactivator, is amplified in a subset of human breast cancers. Here we
show that overexpression of AIB1 in transgenic mice (AIB1-tg) leads to mammary hypertrophy, hyperplasia, abnormal
postweaning involution, and the development of malignant mammary tumors. Tumors are also increased in other organs,
including the pituitary and uterus. AIB1 overexpression increases mammary IGF-I mRNA and serum IGF-I protein levels.
In addition, IGF-I receptor and downstream signaling molecules are activated in primary mammary epithelial cells and
mammary tumor cells derived from AIB1-tg mice. Knockdown of AIB1 expression in cultured AIB1-tg mammary tumor
cells leads to reduced IGF-I mRNA levels and increased apoptosis, suggesting that an autocrine IGF-I loop underlies the
mechanism of AIB1-induced oncogenesis. |
|
Derechos:
|
(c) Cell Press, 2004
info:eu-repo/semantics/restrictedAccess |
|
Tipo de documento:
|
article
publishedVersion |
|
Editor:
|
Elsevier
|
|
Compartir:
|
|
