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Title:
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Computational toolbox towards evolutionary domain mapping of membrane proteins
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Author:
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Crespi i Boixader, Alba
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Other authors:
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Universitat de Vic. Escola Politècnica Superior; Universitat de Vic. Màster Universitari en Anàlisi de Dades Òmiques |
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Notes:
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Curs 2012-2013
Membrane proteins account for about 20% to 30% of all proteins encoded in a typical
genome. They play central roles in multiple cellular processes mediating the interaction of the
cell with its surrounding. Over 60% of all drug targets contain a membrane domain. The
experimental difficulties of obtaining a crystal structural severely limits our ability or
understanding of membrane protein function. Computational evolutionary studies of proteins
are crucial for the prediction of 3D structures. In this project, we construct a tool able to
quantify the evolutionary positive selective pressure on each residue of membrane proteins
through maximum likelihood phylogeny reconstruction. The conservation plot combined with
a structural homology model is also a potent tool to predict those residues that have essentials
roles in the structure and function of a membrane protein and can be very useful in the design
of validation experiments.
Director/a: Mireia Olivella i Alex Peràlvarez |
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Subject(s):
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-Proteïnes de membrana
-Genomes
-Interacció cel·lular |
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Rights:
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Aquest document està subjecte a aquesta llicència Creative Commons
http://creativecommons.org/licenses/by-nc-nd/3.0/es/
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Document type:
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Research/Master Thesis |
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