Universitat Pompeu Fabra: Recent submissions
Now showing items 321-340 of 28732
Evaluation of ChatGPT-4 for the detection of surgical site infections from electronic health records after colorectal surgery: a pilot diagnostic accuracy study
Background: Surveillance of surgical site infection (SSI) relies on manual methods that are time-consuming and prone to subjectivity. This study evaluates the diagnostic accuracy of ChatGPT for detecting SSI from electronic ...
Dual mTOR1/2 inhibitor sapanisertib (FTH-003/TAK-228) in combination with weekly paclitaxel in patients with previously treated metastatic urothelial carcinoma: a phase II open-label study
Background: The PI3K/AKT/mTOR pathway is frequently altered at genomic level in metastatic urothelial carcinoma (mUC). Since mTOR is the last protein in the PI3K signaling cascade, it may have the largest impact on the ...
Convergent evolution in European and Rroma populations reveals pressure exerted by plague on Toll-like receptors
Recent historical periods in Europe have been characterized by severe epidemic events such as plague, smallpox, or influenza that shaped the immune system of modern populations. This study aims to identify signals of ...
The evolutionary history of Drosophila buzzatii. XXXV. Inversion polymorphism and nucleotide variability in different regions of the second chromosome
Inversions are portions of a chromosome where the gene order is reversed relative to a standard reference orientation. Because of reduced levels of recombination in heterokaryotypes, inversions have a potentially important ...
Peer governance practices: an alternative approach to the education of young people in vulnerable contexts
This paper presents the experience of 6 months of work (January to June 2022) with educators and young people aged 16-18 years from a socio-educational organisation in Raval, a vulnerable neighbourhood of Barcelona. It ...
Toward a physical map of Drosophila buzzatii: use of randomly amplified polymorphic DNA polymorphisms and sequence-tagged site landmarks
We present a physical map based on RAPD polymorphic fragments and sequence-tagged sites (STSs) for the repleta group species Drosophila buzzatii. One hundred forty-four RAPD markers have been used as probes for in situ ...
The Pyrenees-Mediterranean Euroregion: functional networks, actor perceptions and expectations
The Euroregions are likely the most prominent expression of cross-border cooperation (CBC) in the European Union (EU). The increase in the number of Euroregions is, however, a relatively recent phenomenon. At the end of ...
Isolated populations as treasure troves in genetic epidemiology: the case of the Basques
The Basques are a culturally isolated population, living across the western border between France and Spain and speaking a non-Indo-European language. They show outlier allele frequencies in the ABO, RH, and HLA loci. To ...
The annotation of the asparagine N-linked glycosylation pathway in the Reactome database
Asparagine N-linked glycosylation is one of the most important forms of protein post-translational modification in eukaryotes and is one of the first metabolic pathways described at a biochemical level. Here, we report a ...
Molecular evolution and network-level analysis of the N-glycosylation metabolic pathway across primates
N-glycosylation is one of the most important forms of protein modification, serving key biological functions in multicellular organisms. N-glycans at the cell surface mediate the interaction between cells and the surrounding ...
Network-level and population genetics analysis of the insulin/TOR signal transduction pathway across human populations
Genes and proteins rarely act in isolation, but they rather operate as components of complex networks of interacting molecules. Therefore, for understanding their evolution, it may be helpful to take into account the ...
