Título:
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Growth differentiation factor 15 (Gdf-15) : A novel biomarker associated with poorer respiratory function in covid-19
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Autor/a:
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Alserawan, Leticia; Peñacoba, Patricia; Orozco Echevarría, Sandra Elizabet; Castillo, Diego; Ortiz, Esther; Martinez-Martinez, Laura; Moga, Esther; Domingo, Pere; Castellvi, Ivan; Juarez, Candido; Mariscal, Anaís; Universitat Autònoma de Barcelona
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Abstract:
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It is essential to find new biomarkers for severity stratification of patients with coronavirus disease (COVID-19). Growth differentiation factor 15 (GDF-15) is upregulated in pathological conditions that involve inflammation and/or oxidative stress. We determined circulating levels of GDF-15 and correlated them with clinical and laboratory parameters reflecting severity in 84 patients with COVID-19, finding that GDF-15 levels were higher in both patients than in 20 healthy controls and were higher in patients with poorer respiratory function. GDF-15 levels also correlated with interleukin-6, C-reactive protein, ferritin and D-dimer levels and with neutrophilia and lymphopenia. Of all the analysed biomarkers, GDF-15 showed the best area under the receiver operating characteristics curve in identifying patients with poor respiratory function. In conclusion, our data support GDF-15 as a biomarker associated with pulmonary impairment in COVID-19 and so can potentially be useful in stratifying COVID-19 cases by severity. |
Materia(s):
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-GDF-15 -COVID-19 -Respiratory function -Inflammation -Biomarker |
Derechos:
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open access
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Article |
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Uri:
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https://ddd.uab.cat/record/264735
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