Título:
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A fermented milk product containing B. lactis CNCM i-2494 improves the tolerance of a plant-based diet in patients with disorders of gut-brain interactions
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Autor/a:
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Le Nevé, Boris; Martinez-De la Torre, Adrian; Tap, Julien; Nieto Ruiz, Adoración; Derrien, Muriel; Cotillard, Aurélie; Faurie, Jean-Michel; Barba Orozco, Elizabeth; Mego Silva, Marianela; Dornic, Quentin; Butler, John; Merino, Xavier; Lobo Álvarez, Beatriz; Pinsach Batet, Ferran; Pozuelo, Marta; Santos, Javier; Guarner, Francisco; Manichanh, Chaysavanh; Azpiroz Vidaur, Fernando
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Abstract:
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Healthy, plant-based diets, rich in fermentable residues, may induce gas-related symptoms. The aim of this exploratory study was to assess the effects of a fermented milk product, containing probiotics, on the tolerance of a healthy diet in patients with disorders of gut-brain interactions (DGBI), complaining of excessive flatulence. In an open design, a 3-day healthy, mostly plant-based diet was administered to patients with DGBI (52 included, 43 completed) before and at the end of 28 days of consumption of a fermented milk product (FMP) containing Bifidobacterium animalis subsp. lactis CNCM I-2494 and lactic acid bacteria. As compared to a habitual diet, the flatulogenic diet increased the perception of digestive symptoms (flatulence score 7.1 ± 1.6 vs. 5.8 ± 1.9; p < 0.05) and the daily number of anal gas evacuations (22.4 ± 12.5 vs. 16.5 ± 10.2; p < 0.0001). FMP consumption reduced the flatulence sensation score (by -1.6 ± 2.2; p < 0.05) and the daily number of anal gas evacuations (by -5.3 ± 8.2; p < 0.0001). FMP consumption did not significantly alter the overall gut microbiota composition, but some changes in the microbiota correlated with the observed clinical improvement. The consumption of a product containing B. lactis CNCM I-2494 improved the tolerance of a healthy diet in patients with DGBI, and this effect may be mediated, in part, by the metabolic activity of the microbiota |
Materia(s):
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-Flatulence -Fermentable carbohydrates -Probiotics -Microbiota -Digestive symptoms -Disorders of gut-brain interactions -B. lactis DN-173010 |
Derechos:
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open access
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Tipo de documento:
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Article |
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Uri:
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https://ddd.uab.cat/record/255895
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