dc.contributor.author |
Virgone, Calogero |
dc.contributor.author |
Lalli, Enzo |
dc.contributor.author |
Bisogno, Gianni |
dc.contributor.author |
Lazzari, Elena |
dc.contributor.author |
Roma, Josep |
dc.contributor.author |
Zin, Angelica |
dc.contributor.author |
Poli, Elena |
dc.contributor.author |
Cecchetto, Giovanni |
dc.contributor.author |
Dall'Igna, Patrizia |
dc.contributor.author |
Alaggio, Rita |
dc.contributor.author |
Universitat Autònoma de Barcelona |
dc.date |
2015 |
dc.date.accessioned |
2022-10-31T08:30:02Z |
dc.date.available |
2022-10-31T08:30:02Z |
dc.date.issued |
2022-10-31 |
dc.identifier |
https://ddd.uab.cat/record/254397 |
dc.identifier |
urn:10.1371/journal.pone.0133019 |
dc.identifier |
urn:oai:ddd.uab.cat:254397 |
dc.identifier |
urn:pmcid:PMC4500404 |
dc.identifier |
urn:pmc-uid:4500404 |
dc.identifier |
urn:pmid:26168243 |
dc.identifier |
urn:oai:pubmedcentral.nih.gov:4500404 |
dc.identifier |
urn:oai:egreta.uab.cat:publications/356a2566-b2dc-468c-9b23-15badad39573 |
dc.identifier |
urn:scopus_id:84940739507 |
dc.identifier.uri |
http://hdl.handle.net/2072/526124 |
dc.format |
application/pdf |
dc.language |
eng |
dc.publisher |
|
dc.relation |
PloS one ; Vol. 10 (july 2015) |
dc.rights |
open access |
dc.rights |
Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original. |
dc.rights |
https://creativecommons.org/licenses/by/4.0/ |
dc.title |
DAX-1 Expression in Pediatric Rhabdomyosarcomas : Another Immunohistochemical Marker Useful in the Diagnosis of Translocation Positive Alveolar Rhabdomyosarcoma |
dc.type |
Article |
dc.description.abstract |
The aim of this study was to investigate the expression of DAX-1 in a series of pediatric rhabdomyosarcomas (RMS) with known translocation and compare it to Ap2β, known to be selectively expressed in ARMS. We revised a series of 71 alveolar rhabdomyosarcomas (ARMS), enrolled in the Italian Protocols RMS 79 and 96, and 23 embryonal rhabdomyosarcomas (ERMS) as controls. Before investigating Ap2β and DAX-1, ARMS were reviewed and reclassified as 48 ARMS and 23 non-ARMS. Translocation positive ARMS showed a characteristic Ap2β/DAX-1+ staining pattern in 78% of cases, while 76% of classic ERMS were negative for both. Ap2β alone was positive in 3.9% of RMS lacking translocation, whereas DAX-1 alone was positive in 25.4%. Conversely, 9% and 6% of translocation positive ARMS were positive only for DAX-1 or Ap2β, respectively. The 23 non-ARMS shared the same phenotype as ERMS but had a higher frequency of DAX-1 expression. DAX-1 is less specific than Ap2β, however it is a sensitive marker for translocation positive ARMS and can be helpful in their diagnosis if used in combination with Ap2β |