Title:
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Macrophage Cholesterol Efflux Downregulation Is Not Associated with Abdominal Aortic Aneurysm (AAA) Progression
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Author:
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Canyelles, Marina; Tondo, Mireia; Lindholt, Jes S.; Santos, David; Fernández, Irati; Gonzalo Calvo, David de; Blanco-Colio, Luis Miguel; Escolà-Gil, Joan Carles; Martín-Ventura, José Luís; Blanco Vaca, Francisco
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Abstract:
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Recent studies have raised the possibility of a role for lipoproteins, including high-density lipoprotein cholesterol (HDLc), in abdominal aortic aneurysm (AAA). The study was conducted in plasmas from 39 large size AAA patients (aortic diameter > 50 mm), 81 small/medium size AAA patients (aortic diameter between 30 and 50 mm) and 38 control subjects (aortic diameter < 30 mm). We evaluated the potential of HDL-mediated macrophage cholesterol efflux (MCE) to predict AAA growth and/or the need for surgery. MCE was impaired in the large aortic diameter AAA group as compared with that in the small/medium size AAA group and the control group. However, no significant difference in HDL-mediated MCE capacity was observed in 3 different progression subgroups (classified according to growth rate < 1 mm per year, between 1 and 5 mm per year or >5 mm per year) in patients with small/medium size AAA. Moreover, no correlation was found between MCE capacity and the aneurysm growth rate. A multivariate Cox regression analysis revealed a significant association between lower MCE capacity with the need for surgery in all AAA patients. Nevertheless, the significance was lost when only small/medium size AAA patients were included. Our results suggest that MCE, a major HDL functional activity, is not involved in AAA progression. |
Subject(s):
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-Abdominal aortic aneurysm -Cardiovascular disease -Cholesterol efflux -HDL -Apoa-i -Aortic diameter -Growth rate -Need for surgery -Reverse cholesterol transport |
Rights:
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open access
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Document type:
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Article |
Published by:
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Share:
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Uri:
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https://ddd.uab.cat/record/252579
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