Títol:
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Microrheometer for Biofluidic Analysis : Electronic Detection of the Fluid-Front Advancement
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Autor/a:
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Méndez-Mora, Lourdes; Cabello-Fusarés, Maria; Ferré-Torres, Josep; Riera-Llobet, Carla; López, Samantha; Trejo-Soto, Claudia; Alarcón Cor, Tomás; Hernández-Machado, Aurora
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Abstract:
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Altres ajuts: Generalitat de Catalunya: 2018/DI-068, 2018/DI-064 |
Abstract:
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The motivation for this study was to develop a microdevice for the precise rheological characterization of biofluids, especially blood. The method presented was based on the principles of rheometry and fluid mechanics at the microscale. Traditional rheometers require a considerable amount of space, are expensive, and require a large volume of sample. A mathematical model was developed that, combined with a proper experimental model, allowed us to characterize the viscosity of Newtonian and non-Newtonian fluids at different shear rates. The technology presented here is the basis of a point-of-care device capable of describing the nonlinear rheology of biofluids by the fluid/air interface front velocity characterization through a microchannel. The proposed microrheometer uses a small amount of sample to deliver fast and accurate results, without needing a large laboratory space. Blood samples from healthy donors at distinct hematocrit percentages were the non-Newtonian fluid selected for the study. Water and plasma were employed as testing Newtonian fluids for validation of the system. The viscosity results obtained for the Newtonian and non-Newtonian fluids were consistent with pertinent studies cited in this paper. In addition, the results achieved using the proposed method allowed distinguishing between blood samples with different characteristics. |
Matèries:
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-Rheometer -Microrheometer -Rheology -Hemorheology -Viscosity -Blood -Plasma |
Drets:
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open access
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Tipus de document:
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Article |
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Uri:
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https://ddd.uab.cat/record/247499
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