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| Título: | EGFR and KRAS Mutations in Lung Parenchyma of Subjects With EGFR/KRAS Wild-Type Lung Adenocarcinoma |
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| Autor/a: | Chalela, Roberto; González-García, Jose Gregorio; Khilzi, Karys; Curull Serrano, Víctor; Sánchez-Font, Albert; Longarón, Raquel; Rodrigo-Calvo, María Teresa; Martín-Ontiyuelo, Clara; Gea Guiral, Joaquim; Bellosillo Paricio, Beatriz |
| Abstract: | Altres ajuts: This study have been funded by Fundació La Marató TV3-201305-30; FUCAP 2015; SEPAR 2015 (Project and; Fellowship). |
| Abstract: | The acquisition of driver mutations in non-tumoral cells appears to be very important during the carcinogenesis of adenocarcinoma (ADC). Recent studies suggest that cancer-related mutations may not necessarily be present only in malignant cells, but also in histologically "healthy cells". Objective: to demonstrate the presence of EGFR or KRAS mutations in non-tumoral lung cells in subjects with ADC and negative mutational status. Results: mutations in EGFR or KRAS oncogenes were identified in the normal lung in 9.7% of the subjects. Exon 21 substitution L858R in EGFR was detected in two cases while the exon 19 deletion E746-A750 in the EGFR, the G12C and G12D substitutions in the KRAS were detected once. One patient presented three different mutations in the normal lung parenchyma (EGFR _L858R, KRAS _G12C and KRAS _G12D). The negative-mutation status of the tumor and the mutations detected in the "normal lung" were confirmed using highly sensitive and specific TaqMan PCR (CAST-PCR). No differences were found in terms of progression, progression-free survival or overall survival during the 18 months follow-up. Conclusions: These results confirm the presence of driver mutations in the histologically normal lung parenchyma cells in the absence of mutations coexisting with the primary tumor. |
| Materia(s): | -Adenocacinoma lung -Driver mutation -EGFR-epidermal growth factor receptor -KRAS -Prognosis |
| Derechos: | open access
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| Tipo de documento: | Article |
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| Uri: | https://ddd.uab.cat/record/248155 |
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