dc.contributor.author |
Rocafort, Muntsa |
dc.contributor.author |
Noguera-Julian, Marc |
dc.contributor.author |
Rivera Pinto, Javier |
dc.contributor.author |
Pastor, Lucía |
dc.contributor.author |
Guillén Montalbán, Yolanda |
dc.contributor.author |
Langhorst, Jost |
dc.contributor.author |
Parera, Mariona |
dc.contributor.author |
Mandomando, Inacio |
dc.contributor.author |
Carrillo, Jorge |
dc.contributor.author |
Urrea, Víctor |
dc.contributor.author |
Rodríguez, Cristina |
dc.contributor.author |
Casadellà, Maria |
dc.contributor.author |
Calle, M. Luz |
dc.contributor.author |
Pérez-Álvarez, Núria |
dc.contributor.author |
Blanco, Julià |
dc.contributor.author |
Naniche, Denise |
dc.contributor.author |
Paredes, Roger |
dc.contributor.author |
Universitat Autònoma de Barcelona |
dc.date |
2019 |
dc.identifier |
https://ddd.uab.cat/record/226459 |
dc.identifier |
urn:10.1186/s40168-019-0687-5 |
dc.identifier |
urn:oai:ddd.uab.cat:226459 |
dc.identifier |
urn:pmid:31078141 |
dc.identifier |
urn:pmcid:PMC6511141 |
dc.identifier |
urn:pmc-uid:6511141 |
dc.identifier |
urn:oai:egreta.uab.cat:publications/5e84e7ec-2c93-405d-977a-98e77f7de4e9 |
dc.identifier |
urn:scopus_id:85065659413 |
dc.identifier |
urn:oai:pubmedcentral.nih.gov:6511141 |
dc.format |
application/pdf |
dc.language |
eng |
dc.publisher |
|
dc.relation |
Instituto de Salud Carlos III PI13-02514 |
dc.relation |
Instituto de Salud Carlos III RD16-0025-0041 |
dc.relation |
Agència de Gestió d'Ajuts Universitaris i de Recerca FI-B00184 |
dc.relation |
Ministerio de Economía y Competitividad MTM2015-64465-C2-1-R |
dc.relation |
Microbiome ; Vol. 7 (may 2019) |
dc.rights |
open access |
dc.rights |
Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original. |
dc.rights |
https://creativecommons.org/licenses/by/4.0/ |
dc.subject |
Microbiome |
dc.subject |
HIV-1 |
dc.subject |
Acute HIV-1 infection |
dc.subject |
HIV-1 pathogenesis |
dc.subject |
AIDS |
dc.title |
Evolution of the gut microbiome following acute HIV-1 infection |
dc.type |
Article |
dc.description.abstract |
In rhesus macaques, simian immunodeficiency virus infection is followed by expansion of enteric viruses but has a limited impact on the gut bacteriome. To understand the longitudinal effects of HIV-1 infection on the human gut microbiota, we prospectively followed 49 Mozambican subjects diagnosed with recent HIV-1 infection (RHI) and 54 HIV-1-negative controls for 9-18 months and compared them with 98 chronically HIV-1-infected subjects treated with antiretrovirals (n = 27) or not (n = 71). We show that RHI is followed by increased fecal adenovirus shedding, which persists during chronic HIV-1 infection and does not resolve with ART. Recent HIV-1 infection is also followed by transient non-HIV-specific changes in the gut bacterial richness and composition. Despite early resilience to change, an HIV-1-specific signature in the gut bacteriome-featuring depletion of Akkermansia, Anaerovibrio, Bifidobacterium, and Clostridium- previously associated with chronic inflammation, CD8+ T cell anergy, and metabolic disorders, can be eventually identified in chronically HIV-1-infected subjects. Recent HIV-1 infection is associated with increased fecal shedding of eukaryotic viruses, transient loss of bacterial taxonomic richness, and long-term reductions in microbial gene richness. An HIV-1-associated microbiome signature only becomes evident in chronically HIV-1-infected subjects. The online version of this article (10.1186/s40168-019-0687-5) contains supplementary material, which is available to authorized users. |