We investigate cobalt ferrite nanoparticles (NPs) supported on large-scale electrodes as oxygen evolution reaction (OER) catalysts. Colloidal CoFeO NPs were loaded on low-cost and high surface area nickel foam (NF) scaffolds. The coating process was optimized for large electrode areas, ensuring a proper distribution of the NPs on the NF that allowed overcoming the electrical conductivity limitations of oxide NPs. We were able to produce CoFeO-coated NFs having 10 cm geometric surface areas with overpotentials below 300 mV for the OER at a current density of 50 mA/cm. Such impressively low overpotentials suggested using CoFeO NP-based electrodes within a water electrolysis device. In this prototype device, stable operating currents up to 500 mA at remarkably low cell-voltages of 1.62 and 1.53 V, at ambient and 50 °C electrolyte temperatures, respectively, were reached during operation periods of up to 50 h. The high electrochemical energy efficiencies reached at 50 mA/cm, 75% and 81% respectively, rendered these devices particularly appealing to be combined with low-cost photovoltaic systems for bias-free hydrogen production. Therefore, CoFeO NP-based electrolysers were coupled to low-cost thin-film silicon solar cells with 13% efficiency to complete a system that afforded solar-to-fuel efficiencies above 10%.