Title:
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FAIM-L regulation of XIAP degradation modulates synaptic long-term depression and axon degeneration
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Author:
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Martínez-Mármol, Ramón; Barneda Zahonero, Bruna; Soto, David; Andrés, Rosa María; Coccia, Elena; Gasull, Xavier; Planells Ferrer, Laura; Moubarak, Rana S.; Soriano García, Eduardo; Comella i Carnicé, Joan Xavier,
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Abstract:
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Caspases have recently emerged as key regulators of axonal pruning and degeneration and of longterm depression (LTD), a long-lasting form of synaptic plasticity. However, the mechanism underlying these functions remains unclear. In this context, XIAP has been shown to modulate these processes. The neuron-specific form of FAIM protein (FAIM-L) is a death receptor antagonist that stabilizes XIAP protein levels, thus preventing death receptor-induced neuronal apoptosis. Here we show that FAIM-L modulates synaptic transmission, prevents chemical-LTD induction in hippocampal neurons, and thwarts axon degeneration after nerve growth factor (NGF) withdrawal. Additionally, we demonstrate that the participation of FAIM-L in these two processes is dependent on its capacity to stabilize XIAP protein levels. Our data reveal FAIM-L as a regulator of axonal degeneration and synaptic plasticity.. |
Rights:
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open access
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https://creativecommons.org/licenses/by/4.0/ |
Document type:
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Article |
Published by:
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Share:
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Uri:
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https://ddd.uab.cat/record/206003
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